Weight change and mortality and cardiovascular outcomes in patients with new-onset diabetes mellitus: a nationwide cohort study
DC Field | Value | Language |
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dc.contributor.author | Kim, Mee Kyoung | - |
dc.contributor.author | Han, Kyungdo | - |
dc.contributor.author | Koh, Eun Sil | - |
dc.contributor.author | Kim, Eun Sook | - |
dc.contributor.author | Lee, Min-Kyung | - |
dc.contributor.author | Nam, Ga Eun | - |
dc.contributor.author | Kwon, Hyuk-Sang | - |
dc.date.available | 2020-09-14T08:12:22Z | - |
dc.date.created | 2020-06-18 | - |
dc.date.issued | 2019-03 | - |
dc.identifier.issn | 1475-2840 | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/39069 | - |
dc.description.abstract | BackgroundBecause weight control is a cornerstone of diabetes management, it is important to understand the relationship of weight change to risk of cardiovascular disease (CVD) among patients with type 2 diabetes mellitus (DM). We aimed to investigate whether changes in weight early after diagnosis influence the incidence of CVD and all-cause mortality in patients with type 2 DM.MethodsUsing nationally representative data from the Korean National Health Insurance System, 173,246 subjects with new-onset DM who underwent health examinations during 2007-2012 were included. Weight was measured at the time of diabetes diagnosis and 2years later. Weight change over 2years was divided into five categories of 5% weight change, from weight loss -10% to weight gain 10%.ResultsThere were 3113 deaths (1.8%), 2060 cases of stroke (1.2%), and 1767 myocardial infarctions (MIs) (1.0%) during a median follow-up of 5.5years. Subjects with weight gain 10% had a significantly higher risk of stroke (hazard ratio [HR] 1.51, 95% confidence interval [CI] 1.23-1.84), compared with the group with stable weight. There was no significant association between weight change after diagnosis of DM and incident MI. All-cause mortality showed a U-shaped curve according to weight change. The group with weight loss -10% had the highest HR for all-cause mortality (HR 1.86; 95% CI 1.61-2.14) and the HR for weight gain 10% was 1.61 (95% CI 1.37-1.89).ConclusionsWeight changes of more than 10% after diabetes diagnosis were associated with higher mortality and over 10% weight gain was associated with increased risk of stroke. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.relation.isPartOf | CARDIOVASCULAR DIABETOLOGY | - |
dc.title | Weight change and mortality and cardiovascular outcomes in patients with new-onset diabetes mellitus: a nationwide cohort study | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/s12933-019-0838-9 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | CARDIOVASCULAR DIABETOLOGY, v.18 | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000462341700001 | - |
dc.identifier.scopusid | 2-s2.0-85063142456 | - |
dc.citation.title | CARDIOVASCULAR DIABETOLOGY | - |
dc.citation.volume | 18 | - |
dc.contributor.affiliatedAuthor | Han, Kyungdo | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordAuthor | Weight changes | - |
dc.subject.keywordAuthor | Type 2 diabetes mellitus | - |
dc.subject.keywordAuthor | Cardiovascular disease | - |
dc.subject.keywordPlus | BODY-MASS INDEX | - |
dc.subject.keywordPlus | LIFE-STYLE INTERVENTION | - |
dc.subject.keywordPlus | ALL-CAUSE | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | HEALTH | - |
dc.subject.keywordPlus | VARIABILITY | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | OVERWEIGHT | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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