A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases
- Authors
- Zhu, Zhaozhong; Lee, Phil H.; Chaffin, Mark D.; Chung, Wonil; Loh, Po-Ru; Lu, Quan; Christiani, David C.; Liang, Liming
- Issue Date
- Jun-2018
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- NATURE GENETICS, v.50, no.6, pp.857 - +
- Journal Title
- NATURE GENETICS
- Volume
- 50
- Number
- 6
- Start Page
- 857
- End Page
- +
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/39195
- DOI
- 10.1038/s41588-018-0121-0
- ISSN
- 1061-4036
- Abstract
- Clinical and epidemiological data suggest that asthma and allergic diseases are associated and may share a common genetic etiology. We analyzed genome-wide SNP data for asthma and allergic diseases in 33,593 cases and 76,768 controls of European ancestry from UK Biobank. Two publicly available independent genome-wide association studies were used for replication. We have found a strong genome-wide genetic correlation between asthma and allergic diseases (rg = 0.75, P = 6.84 x 10(-62)). Cross-trait analysis identified 38 genome-wide significant loci, including 7 novel shared loci. Computational analysis showed that shared genetic loci are enriched in immune/inflammatory systems and tissues with epithelium cells. Our work identifies common genetic architectures shared between asthma and allergy and will help to advance understanding of the molecular mechanisms underlying co-morbid asthma and allergic diseases.
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Collections - College of Natural Sciences > ETC > 1. Journal Articles
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