pH-sensitive mesalazine carrier for colon-targeted drug delivery: A two-fold composition of mesalazine with a clay and alginate
DC Field | Value | Language |
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dc.contributor.author | Hong, Hye-Jin | - |
dc.contributor.author | Kim, Jiwoong | - |
dc.contributor.author | Suh, Yong Jae | - |
dc.contributor.author | Kim, Daeyoung | - |
dc.contributor.author | Roh, Ki-Min | - |
dc.contributor.author | Kang, Ilmo | - |
dc.date.available | 2020-09-14T09:05:39Z | - |
dc.date.created | 2019-12-03 | - |
dc.date.issued | 2017-11 | - |
dc.identifier.issn | 1598-5032 | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/39273 | - |
dc.description.abstract | The release of mesalazine, an anti-inflammatory drug for Crohn's disease, should be deferred while delivering along the gastrointestinal tract to maximize drug absorption in the colon. To that end, we intercalated mesalazine into a clay mineral, montmorillonite (MMT), and we encapsulated the resulting composite inside a pHsensitive polymer, an alginate hydrogel bead. Once intercalated between the microscopic MMT layers, the mesalazine is prevented from dissolution during encapsulation into the alginate beads. As the resulting mesalazine-clay-alginate (MCA) bead is covered with a protective alginate layer, the mesalazine does not dissolve in acidic gastric conditions. In in vitro release tests, the MCA beads exhibited less than 5% mesalazine release in gastric solution, while similar to 20% was released over 7 h in the intestinal condition. Our results demonstrate that the MCA bead is a highly effective, biocompatible means of mesalazine delivery to the colon. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.relation.isPartOf | MACROMOLECULAR RESEARCH | - |
dc.title | pH-sensitive mesalazine carrier for colon-targeted drug delivery: A two-fold composition of mesalazine with a clay and alginate | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s13233-017-5150-5 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | MACROMOLECULAR RESEARCH, v.25, no.11, pp.1145 - 1152 | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000417079300014 | - |
dc.identifier.scopusid | 2-s2.0-85029901034 | - |
dc.citation.endPage | 1152 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1145 | - |
dc.citation.title | MACROMOLECULAR RESEARCH | - |
dc.citation.volume | 25 | - |
dc.contributor.affiliatedAuthor | Kim, Jiwoong | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordAuthor | targeted drug delivery | - |
dc.subject.keywordAuthor | side effect | - |
dc.subject.keywordAuthor | smectite | - |
dc.subject.keywordAuthor | alginate hydrogel | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | MONTMORILLONITE | - |
dc.subject.keywordPlus | BEADS | - |
dc.subject.keywordPlus | MESALAMINE | - |
dc.subject.keywordPlus | CHITOSAN | - |
dc.subject.keywordPlus | CALCIUM | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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