Biomimetic polymeric nanoparticle-based photodynamic immunotherapy and protection against tumor rechallenge
DC Field | Value | Language |
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dc.contributor.author | Kim, Dongyoon | - |
dc.contributor.author | Byun, Junho | - |
dc.contributor.author | Park, Jinwon | - |
dc.contributor.author | Lee, Yeon | - |
dc.contributor.author | Shim, Gayong | - |
dc.contributor.author | Oh, Yu-Kyoung | - |
dc.date.available | 2020-10-22T08:40:11Z | - |
dc.date.created | 2020-10-22 | - |
dc.date.issued | 2020-02 | - |
dc.identifier.issn | 2047-4830 | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/39681 | - |
dc.description.abstract | In this study, we sought to design a bionanomaterial that could exert anticancer effects against primary tumors and protect against rechallenged tumors via photodynamic immunotherapy. As a biomaterial, we used an amphiphilic phenylalanine derivative of poly-gamma glutamic acid, which forms nanoparticles by self-assembly. For anticancer effects, we co-entrapped hydrophobic chlorin e6 and monophosphoryl lipid A in the core of the plain amphiphilic phenylalanine nanoparticles (AN), to generate M/C/AN. For comparison, we used plain AN and chlorin e6-loaded AN (C/AN). In vitro studies showed that B16F10 cancer cells treated with C/AN or M/C/AN generated reactive oxygen species and exhibited an enhanced surface display of calreticulin upon exposure to 660 nm light irradiation. C/AN and M/C/AN exerted similar photodynamic anticancer effects; however, M/C/AN, but not C/AN, induced in vitro dendritic cell maturation. Our biodistribution study revealed that C/AN and M/C/AN showed higher accumulation at the tumor tissues compared to that seen in the free chlorin e6-treated group. In B16F10 tumor-bearing mice, the intravenous injection of C/AN or M/C/AN showed similar photodynamic anticancer effects against primary tumors. However, the growth of rechallenged tumors was more significantly inhibited in the M/C/ AN group compared to the C/AN group. At day 40 after inoculation of the primary tumor, M/C/ANtreated mice showed 100% survival, whereas the other groups showed 0% survival. In the tumor microenvironment, higher infiltration of CD8+ T cells was observed in the M/C/AN group compared to the other groups. Our results suggest that AN co-loaded with a photosensitizer and an immune stimulant may hold great potential for use in photodynamic immunotherapy to inhibit both primary and metastatic tumors. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.relation.isPartOf | BIOMATERIALS SCIENCE | - |
dc.title | Biomimetic polymeric nanoparticle-based photodynamic immunotherapy and protection against tumor rechallenge | - |
dc.type | Article | - |
dc.identifier.doi | 10.1039/c9bm01704f | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOMATERIALS SCIENCE, v.8, no.4, pp.1106 - 1116 | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000517148800014 | - |
dc.citation.endPage | 1116 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1106 | - |
dc.citation.title | BIOMATERIALS SCIENCE | - |
dc.citation.volume | 8 | - |
dc.contributor.affiliatedAuthor | Shim, Gayong | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordPlus | GAMMA-GLUTAMYL-TRANSFERASE | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | IMMUNITY | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | SAFETY | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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