Tannic acid-functionalized boron nitride nanosheets for theranostics
- Authors
- Shim, G.; Ko, S.; Park, J.Y.; Suh, J.H.; Le, Q.-V.; Kim, D.; Kim, Y.B.; Im, G.H.; Kim, H.N.; Choe, Y.S.; Cho, J.; Kim, S.; Oh, Y.-K.
- Issue Date
- Nov-2020
- Publisher
- Elsevier B.V.
- Keywords
- Boron nitride nanosheets; Functionalization; Magnetic resonance imaging; Tannic acid-iron coordination complex; Theranostics
- Citation
- Journal of Controlled Release, v.327, pp.616 - 626
- Journal Title
- Journal of Controlled Release
- Volume
- 327
- Start Page
- 616
- End Page
- 626
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/39698
- DOI
- 10.1016/j.jconrel.2020.09.009
- ISSN
- 0168-3659
- Abstract
- Here, we report a tannic acid-Fe3+ coordination complex coating that confers magnetic resonance imaging (MRI) theranostic properties to inert nanomaterials. Boron nitride nanosheets (BNS), which lack magnetic field and light responsiveness, were used as a model nonfunctional nanomaterial. Among various catechol derivatives tested (i.e., dopamine, 3,4-dihydroxyphenylacetic acid, gallic acid, and tannic acid), a coating of tannic acid-Fe3+ coordination complex provided the highest magnetic field relaxivity and near infrared (NIR) laser light responsiveness. An in vitro study showed that KB tumor cells treated with tannic acid-Fe3+ coordination complex adsorbed on BNS (TA-Fe/BNS) exhibited higher T1-weighted magnetic resonance contrast compared with plain BNS, and BNS coated with tannic acid or Fe alone. NIR irradiation at 808 nm caused a significant increase in KB tumor cell death after treatment with TA-Fe/BNS compared with other treatments. In vivo MRI imaging revealed tumor accumulation of intravenously administered TA-Fe/BNS. Guided by MRI information, application of focused laser irradiation onto tumor tissues resulted in complete tumor ablation. These results support the potential of TA-Fe/BNS for MRI theranostics. Moreover, this study suggests the wide applicability of TA-Fe noncovalent coating as biocompatible and facile tool for converting nonfunctional early-generation nanomaterials into functional new nanomaterials, opening new opportunities for their use in translational biomedical applications such as MRI theranostics. © 2020 Elsevier B.V.
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Collections - College of Natural Sciences > School of Systems and Biomedical Science > 1. Journal Articles
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