Hypertriglyceridemia Is an Independent Risk Factor for Cardiovascular Diseases in Korean Adults Aged 30–49 Years: a Nationwide Population-Based Studyopen accessHypertriglyceridemia Is an Independent Risk Factor for Cardiovascular Diseases in Korean Adults Aged 30–49 Years: a Nationwide Population-Based Study
- Other Titles
- Hypertriglyceridemia Is an Independent Risk Factor for Cardiovascular Diseases in Korean Adults Aged 30–49 Years: a Nationwide Population-Based Study
- Authors
- 구보경; 박상현; 한경도; 문민경
- Issue Date
- Jan-2021
- Publisher
- 한국지질동맥경화학회
- Keywords
- Cardiovascular diseases; Triglycerides; Insurance claims analysis
- Citation
- Journal of Lipid and Atherosclerosis, v.10, no.1, pp.88 - 98
- Journal Title
- Journal of Lipid and Atherosclerosis
- Volume
- 10
- Number
- 1
- Start Page
- 88
- End Page
- 98
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/40234
- DOI
- 10.12997/jla.2021.10.1.88
- ISSN
- 2287-2892
- Abstract
- Objective This study was conducted to estimate the incidence of cardiovascular disease (CVD) independently from low-density lipoprotein (LDL) cholesterol according to triglyceride (TG) levels in young adults.
Methods Subjects aged 30–49 years with data from routine health check-ups provided by the National Health Insurance Service during 2009 were selected. The primary outcome was incident CVD, defined as a composite of ischemic heart disease and ischemic stroke during the follow-up period from 2009 to 2018.
Results The mean age of study subjects (n=1,823,537) was 40.1±5.7 years, and the median follow-up period was 8.3 years. The quartiles of serum TG levels at the baseline were calculated: Q1, <74 mg/dL; Q2, 74–108 mg/dL; Q3, 109–166 mg/dL; and Q4: >166 mg/dL. The highest quartile of TG levels (Q4) had a significantly higher risk of the primary outcome than Q1 (hazard ratio [HR], 2.40 [95% confidence interval; CI, 2.33–2.47]). Q2 and Q3 also experienced the primary outcome more frequently than Q1 (HR, 1.37 [95% CI, 1.33–1.42] and HR, 1.80 [95% CI, 1.75–1.86], respectively). Even after adjustment for age, sex, obesity, alcohol drinking amount, smoking, LDL cholesterol, diabetes mellitus, hypertension, lipid-lowering medication use, and family history of CVD, there was a significant dose-response relationship between TG quartiles and the risk of the primary outcome (HR per quartile, 1.13 [95% CI, 1.12–1.14]).
Conclusion In conclusion, in the Korean population aged 30–49 years, high TG levels independently increased future CVD risk in both men and women.
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