Characterization of HIV-1 recombinant and subtype B near full-length genome among men who have sex with men in South Korea
- Authors
- Ryou, S.; Yoo, M.; Kim, K.; Kim, S.; Kim, S.I.; Kim, Y.J.; Park, D.W.; Choi, J.Y.; Kim, H.Y.; Kim, J.H.; Song, J.Y.; Kim, S.-W.; Chang, H.-H.; Choi, B.Y.; Kee, M.-K.
- Issue Date
- 18-Feb-2021
- Publisher
- Nature Research
- Citation
- Scientific Reports, v.11, no.1
- Journal Title
- Scientific Reports
- Volume
- 11
- Number
- 1
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/40647
- DOI
- 10.1038/s41598-021-82872-3
- ISSN
- 2045-2322
- Abstract
- In Korea, subtype B is the predominant variant of HIV-1, but full genome sequencing and analysis of its viral variants are lacking. We performed near full-length genome (NFLG) sequencing and phylogenetic and recombination analyses of fifty plasma samples from HIV-positive men who have sex with men (MSM) from a Korea HIV/AIDS cohort study. Viral genomes were amplified and the near-full-length sequences were determined using next-generation sequencing (NGS) and Sanger sequencing. We focused on the HIV-1 subtype classification and identification of HIV recombinants. Twelve HIV-1 NFLGs were determined: ten were subtyped as pure HIV-1 subtype B and two recombinant strains as a common subtype CRF07_BC, and a novel subtype CRF43_02G recombined with CRF02_AG again, or a new CRF02_AG and subtype G recombinant. For the ten NFLGs determined by NGS, “the novel recombinant emerged at approximately 2003 and the other nine subtype B about 2004 or 2005”. This is the first report analyzing HIV-1 NFLG, including recombinants and clinical characteristics, by subtype among MSM in Korea. Our results provide novel insights for understanding the recombinants in the HIV-1 epidemic in Korea. © 2021, The Author(s).
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Natural Sciences > School of Systems and Biomedical Science > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/40647)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.