The histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus
DC Field | Value | Language |
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dc.contributor.author | Huisman, C. | - |
dc.contributor.author | Kim, Y.A. | - |
dc.contributor.author | Jeon, S. | - |
dc.contributor.author | Shin, B. | - |
dc.contributor.author | Choi, J. | - |
dc.contributor.author | Lim, S.J. | - |
dc.contributor.author | Youn, S.M. | - |
dc.contributor.author | Park, Y. | - |
dc.contributor.author | Medha, K.C. | - |
dc.contributor.author | Kim, S. | - |
dc.contributor.author | Lee, S.-K. | - |
dc.contributor.author | Lee, S. | - |
dc.contributor.author | Lee, J.W. | - |
dc.date.available | 2021-03-10T08:40:16Z | - |
dc.date.created | 2021-03-10 | - |
dc.date.issued | 2021-01-11 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/40650 | - |
dc.description.abstract | In humans, inactivating mutations in MLL4, which encodes a histone H3-lysine 4-methyltransferase, lead to Kabuki syndrome (KS). While dwarfism is a cardinal feature of KS, the underlying etiology remains unclear. Here we report that Mll4 regulates the development of growth hormone-releasing hormone (GHRH)-producing neurons in the mouse hypothalamus. Our two Mll4 mutant mouse models exhibit dwarfism phenotype and impairment of the developmental programs for GHRH-neurons. Our ChIP-seq analysis reveals that, in the developing mouse hypothalamus, Mll4 interacts with the transcription factor Nrf1 to trigger the expression of GHRH-neuronal genes. Interestingly, the deficiency of Mll4 results in a marked reduction of histone marks of active transcription, while treatment with the histone deacetylase inhibitor AR-42 rescues the histone mark signature and restores GHRH-neuronal production in Mll4 mutant mice. Our results suggest that the developmental dysregulation of Mll4-directed epigenetic control of transcription plays a role in the development of GHRH-neurons and dwarfism phenotype in mice. © 2021, The Author(s). | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Nature Research | - |
dc.relation.isPartOf | Nature Communications | - |
dc.title | The histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41467-020-20511-7 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Nature Communications, v.12, no.1 | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000657631000001 | - |
dc.identifier.scopusid | 2-s2.0-85099252585 | - |
dc.citation.number | 1 | - |
dc.citation.title | Nature Communications | - |
dc.citation.volume | 12 | - |
dc.contributor.affiliatedAuthor | Kim, S. | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordPlus | growth hormone releasing factor | - |
dc.subject.keywordPlus | histone | - |
dc.subject.keywordPlus | histone h3 lysine 4 methyltransferase | - |
dc.subject.keywordPlus | histone methyltransferase | - |
dc.subject.keywordPlus | nuclear respiratory factor 1 | - |
dc.subject.keywordPlus | rec 2282 | - |
dc.subject.keywordPlus | transcription factor Nrf1 | - |
dc.subject.keywordPlus | unclassified drug | - |
dc.subject.keywordPlus | arylbutyric acid derivative | - |
dc.subject.keywordPlus | growth hormone releasing factor | - |
dc.subject.keywordPlus | histone lysine methyltransferase | - |
dc.subject.keywordPlus | MLL4 protein, mouse | - |
dc.subject.keywordPlus | Nrf1 protein, mouse | - |
dc.subject.keywordPlus | nuclear respiratory factor 1 | - |
dc.subject.keywordPlus | OSU-HDAC42 compound | - |
dc.subject.keywordPlus | transcription factor | - |
dc.subject.keywordPlus | biological development | - |
dc.subject.keywordPlus | etiology | - |
dc.subject.keywordPlus | gene expression | - |
dc.subject.keywordPlus | hormone | - |
dc.subject.keywordPlus | inhibitor | - |
dc.subject.keywordPlus | mutation | - |
dc.subject.keywordPlus | nervous system | - |
dc.subject.keywordPlus | phenotype | - |
dc.subject.keywordPlus | protein | - |
dc.subject.keywordPlus | rodent | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | animal model | - |
dc.subject.keywordPlus | animal tissue | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | brain development | - |
dc.subject.keywordPlus | brain nerve cell | - |
dc.subject.keywordPlus | chromatin immunoprecipitation sequencing | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | dwarfism | - |
dc.subject.keywordPlus | embryo | - |
dc.subject.keywordPlus | epigenetics | - |
dc.subject.keywordPlus | gene expression | - |
dc.subject.keywordPlus | genetic transcription | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | human cell | - |
dc.subject.keywordPlus | hypothalamus | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | mouse | - |
dc.subject.keywordPlus | mouse mutant | - |
dc.subject.keywordPlus | nerve cell differentiation | - |
dc.subject.keywordPlus | neurosecretory cell | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | phenotype | - |
dc.subject.keywordPlus | animal | - |
dc.subject.keywordPlus | biological model | - |
dc.subject.keywordPlus | biosynthesis | - |
dc.subject.keywordPlus | cytology | - |
dc.subject.keywordPlus | dwarfism | - |
dc.subject.keywordPlus | embryology | - |
dc.subject.keywordPlus | gene expression regulation | - |
dc.subject.keywordPlus | genetic epigenesis | - |
dc.subject.keywordPlus | HEK293 cell line | - |
dc.subject.keywordPlus | hypothalamus | - |
dc.subject.keywordPlus | knockout mouse | - |
dc.subject.keywordPlus | mammalian embryo | - |
dc.subject.keywordPlus | metabolism | - |
dc.subject.keywordPlus | nerve cell | - |
dc.subject.keywordPlus | nucleotide sequence | - |
dc.subject.keywordPlus | Animals | - |
dc.subject.keywordPlus | Base Sequence | - |
dc.subject.keywordPlus | Dwarfism | - |
dc.subject.keywordPlus | Embryo, Mammalian | - |
dc.subject.keywordPlus | Epigenesis, Genetic | - |
dc.subject.keywordPlus | Gene Expression Regulation, Developmental | - |
dc.subject.keywordPlus | Growth Hormone-Releasing Hormone | - |
dc.subject.keywordPlus | HEK293 Cells | - |
dc.subject.keywordPlus | Histone-Lysine N-Methyltransferase | - |
dc.subject.keywordPlus | Humans | - |
dc.subject.keywordPlus | Hypothalamus | - |
dc.subject.keywordPlus | Male | - |
dc.subject.keywordPlus | Mice, Knockout | - |
dc.subject.keywordPlus | Models, Biological | - |
dc.subject.keywordPlus | Neurons | - |
dc.subject.keywordPlus | Nuclear Respiratory Factor 1 | - |
dc.subject.keywordPlus | Phenylbutyrates | - |
dc.subject.keywordPlus | Transcription Factors | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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