Comparison of early postoperative cytokine changes in patients undergoing intubated and non-intubated thoracic surgery: a randomized controlled trial
- Authors
- Jeon, Joonpyo; Sung, Sookwhan; Moon, Youngkyu; Koo, Jungmin; Hyun, Kwanyong; Han, Kyungdo; Hwang, Wonjung
- Issue Date
- Mar-2021
- Publisher
- NLM (Medline)
- Keywords
- Cytokine; Infection and inflammation; Lung cancer; Thoracic surgery
- Citation
- Interactive cardiovascular and thoracic surgery, v.32, no.3, pp.343 - 350
- Journal Title
- Interactive cardiovascular and thoracic surgery
- Volume
- 32
- Number
- 3
- Start Page
- 343
- End Page
- 350
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/40802
- DOI
- 10.1093/icvts/ivaa265
- ISSN
- 1569-9293
- Abstract
- OBJECTIVES: The inflammatory response after surgery is associated with patient prognosis. Patients who undergo thoracic surgery exhibit a profound systemic inflammatory response due to the surgical procedures used and application of one-lung ventilation. The aim of this study was to compare perioperative inflammatory changes in patients after intubated and non-intubated thoracic surgery for primary lung cancer resection. METHODS: This prospective randomized controlled study included forty patients who underwent surgical resection for stage I non-small-cell lung cancer. Blood samples for cytokine analysis were collected just before induction, at 1 and 24 h after surgery. Levels of the pro-inflammatory cytokine and anti-inflammatory cytokines were measured using quantitative sandwich enzyme immunoassay kits. RESULTS: The basal values of cytokines were comparable between 2 groups. Within each group, the postoperative levels of interleukin (IL)-1, IL-6 and tumour necrosis factor-α increased, while those of IL-4 and IL-10 did not change significantly. The levels of IL-6 and tumour necrosis factor-α were significantly lower in group NI at 1 and 24 h postoperatively. Other cytokines did not differ in both groups during postoperative period. The IL-6/IL-10 ratio at 1 h after surgery was lower in non-intubated patients than in intubated patients, but there was no difference at 24 h after surgery. CONCLUSIONS: Non-intubated thoracic surgery may attenuate the early inflammatory cytokine changes following major resection for primary lung cancer compared with intubated conventional surgery. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov registry number NCT04007354. © The Author(s) 2020. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Natural Sciences > ETC > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.