Association of High-Density Lipoprotein Cholesterol Variability and the Risk of Developing Parkinson Disease
- Authors
- Park, J.-H.; Lee, C.-W.; Nam, M.J.; Kim, H.; Kwon, D.-Y.; Yoo, J.W.; Lee, K.N.; Han, K.; Jung, J.-H.; Park, Y.-G.; Kim, D.-H.
- Issue Date
- 9-Mar-2021
- Publisher
- NLM (Medline)
- Citation
- Neurology, v.96, no.10, pp.e1391 - e1401
- Journal Title
- Neurology
- Volume
- 96
- Number
- 10
- Start Page
- e1391
- End Page
- e1401
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/41195
- DOI
- 10.1212/WNL.0000000000011553
- ISSN
- 0028-3878
- Abstract
- OBJECTIVE: To investigate the longitudinal association among high-density lipoprotein cholesterol (HDL-C) level, HDL-C variability, and the risk of developing Parkinson disease (PD). METHODS: We conducted a nationwide, population-based cohort study. We included 382,391 patients aged ≥65 years who underwent at least 3 health examinations provided by the Korean National Health Insurance System from 2008 to 2013 and followed up until 2017. Individuals with a history of PD and missing values were excluded (n = 1,987). We assessed HDL-C variability using 3 indices, including variability independent of the mean (VIM). A multivariate-adjusted Cox proportional hazards regression analysis was performed. RESULTS: Among the 380,404 participants, 2,733 individuals were newly diagnosed with PD during a median follow-up period of 5 years. The lowest quartile (Q1) group of baseline HDL-C and mean HDL-C was associated with increased PD incidence as compared with the highest quartile (Q4) group (adjusted hazard ratio [aHR], 1.20; 95% confidence interval [CI], 1.08-1.34; and aHR, 1.16; 95% CI, 1.04-1.30, respectively). The Q4 group of HDL-C variability (VIM) was associated with increased PD incidence compared to the Q1 group (aHR, 1.19; 95% CI, 1.06-1.33). The group with the Q1 of baseline HDL-C and with the Q4 of HDL-C variability had the highest risk of PD incidence (aHR, 1.6; 95% CI, 1.31-1.96). CONCLUSION: Lower HDL-C level and greater HDL-C variability were associated with a higher incidence of PD. © 2021 American Academy of Neurology.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Natural Sciences > ETC > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/41195)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.