Association between obstructive sleep apnea and thyroid cancer incidence: a national health insurance data study

Abstract

Purpose Little is known about the incidence of thyroid cancer in patients with obstructive sleep apnea (OSA). This study aimed to evaluate whether OSA is associated with the incidence of thyroid cancer based on the Korea National Health Insurance Service (KNHIS) database. Methods This study was designed as a retrospective cohort data analysis of the KNHIS dataset. A total of 198,574 patients who were over 20 years of age and had been newly diagnosed with OSA between 2007 and 2014 were enrolled. A control group of 992,870 individuals was selected based on propensity score matching by age and sex. The mean follow-up duration was 4.5 +/- 2.3 years. The primary endpoint was the incidence of newly diagnosed thyroid cancer. Results The hazard ratio (HR) for thyroid cancer incidence among OSA patients compared to the control was 1.72 (95% confidence interval [CI] 1.60-1.84) based on Model 1 (not adjusted by any covariate) and 1.64 (95% CI 1.53-1.76) based on Model 2 (adjusted by income level, diabetes, hypertension, and dyslipidemia). Thyroid cancer incidence was significantly higher in male patients (HR = 1.93, 95% CI 1.74-2.12) than female ones (HR = 1.39, 95% CI 1.26-1.54). When compared by age, the HR of thyroid cancer was higher in middle-aged (40 <= age < 65 years) patients (HR = 1.68, 95% CI 1.55-1.83) than in young (20 <= age < 40 years, HR = 1.53, 95% CI 1.32-1.77) or old (65 <= age, HR = 1.28, 95% CI 0.94-1.74) patients. Conclusion OSA may increase the risk of developing thyroid cancer, especially in middle-aged men.