Body weight variability and the risk of cardiovascular outcomes in patients with nonalcoholic fatty liver disease
- Authors
- Kim, Mi Na; Han, Kyungdo; Yoo, Juhwan; Ha, Yeonjung; Chon, Young Eun; Lee, Ju Ho; Simon, Tracey G.; Chan, Andrew T.; Hwang, Seong Gyu
- Issue Date
- 28-Apr-2021
- Publisher
- NATURE RESEARCH
- Citation
- SCIENTIFIC REPORTS, v.11, no.1
- Journal Title
- SCIENTIFIC REPORTS
- Volume
- 11
- Number
- 1
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/41376
- DOI
- 10.1038/s41598-021-88733-3
- ISSN
- 2045-2322
- Abstract
- We investigated the association between body weight variability and the risks of cardiovascular disease and mortality in patients with nonalcoholic fatty liver disease (NAFLD) using large-scale, nationwide cohort data. We included 726,736 individuals with NAFLD who underwent a health examination between 2009 and 2010. NAFLD was defined as a fatty liver index >= 60, after excluding significant alcohol intake, viral hepatitis, and liver cirrhosis. Body weight variability was assessed using four indices, including variability independent of the mean (VIM). During a median 8.1-year follow-up, we documented 11,358, 14,714, and 22,164 cases of myocardial infarction (MI), stroke, and all-cause mortality, respectively. Body weight variability was associated with an increased risk of MI, stroke, and mortality after adjusting for confounding variables. The hazard ratios (HRs) (95% confidence intervals) for the highest quartile, compared with the lowest quartile, of VIM for body weight were 1.15 (1.10-1.20), 1.22 (1.18-1.26), and 1.56 (1.53-1.62) for MI, stroke, and all-cause mortality, respectively. Body weight variability was associated with increased risks of MI, stroke, and all-cause mortality in NAFLD patients. Appropriate interventions to maintain a stable weight could positively affect health outcomes in NAFLD patients.
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