Behcet's Disease Is Associated with Multiple Sclerosis and Rheumatoid Arthritis: A Korean Population-Based Study
- Authors
- Jung, Jin Hyung; Han, Kyung Do; Lee, Young Bok; Park, Yong Gyu
- Issue Date
- Jan-2022
- Publisher
- KARGER
- Keywords
- Beh& #231; et& #8217; s disease; Rheumatoid arthritis; Multiple sclerosis; Nationwide population study
- Citation
- DERMATOLOGY, v.238, no.1, pp.86 - 91
- Journal Title
- DERMATOLOGY
- Volume
- 238
- Number
- 1
- Start Page
- 86
- End Page
- 91
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/41928
- DOI
- 10.1159/000514634
- ISSN
- 1018-8665
- Abstract
- Background: No epidemiologic study has previously reported on the associations among Behcet's disease (BD) and autoimmune disorders. Objectives: To investigate the association between BD and the autoimmune disorders multiple sclerosis and rheumatoid arthritis. Methods: Medical records of patients newly diagnosed with BD (n = 6,214) in 2012-2017 were analyzed using data entered into a large, nationwide database from 2007 to 2017. An age- and sex-matched control population of individuals without BD was sampled at a ratio of controls:BD cases of 3:1 (n = 18,642). Both cohorts were analyzed for the presence of multiple sclerosis or rheumatoid arthritis within a minimum of 5 years prior to their BD diagnosis. Results: Patients with BD had significantly higher odds ratios (ORs) for multiple sclerosis (8.85 [95% CI 2.36-33.17]) and rheumatoid arthritis (4.62 [95% CI 3.35-6.35]) than the control group after adjustment for diabetes mellitus, hypertension, and dyslipidemia. BD patients aged <40 years had a higher proportion of rheumatoid arthritis (OR 23.91, 95% CI 5.50-103.9) than older patients (OR 3.96, 95% CI 2.83-5.54). Conclusion: Our results suggest that BD is associated with multiple sclerosis and rheumatoid arthritis.
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