Risk of early mortality and cardiovascular disease according to the presence of recently diagnosed diabetes and requirement for insulin treatment: A nationwide study
- Authors
- Lee, You-Bin; Han, Kyungdo; Kim, Bongsung; Choi, Min Sun; Park, Jiyun; Kim, Minyoung; Jin, Sang-Man; Hur, Kyu Yeon; Kim, Gyuri; Kim, Jae Hyeon
- Issue Date
- Oct-2021
- Publisher
- WILEY
- Keywords
- Insulin; Mortality; Type 2 diabetes mellitus
- Citation
- JOURNAL OF DIABETES INVESTIGATION, v.12, no.10, pp.1855 - 1863
- Journal Title
- JOURNAL OF DIABETES INVESTIGATION
- Volume
- 12
- Number
- 10
- Start Page
- 1855
- End Page
- 1863
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/41933
- DOI
- 10.1111/jdi.13539
- ISSN
- 2040-1116
- Abstract
- Aims/Introduction We estimated the hazards of cardiovascular diseases (CVDs) and early all-cause mortality in Korean adults according to the presence of recently diagnosed type 2 diabetes (type 2 diabetes for <5 years) and insulin use. Materials and Methods We used the Korean National Health Insurance Service-National Sample Cohort database (2002-2015) for this longitudinal population-based study. Among adults aged >= 40 years without baseline CVD, individuals without diabetes or with recently diagnosed type 2 diabetes were selected (N = 363,919). The hazard ratios (HRs) for myocardial infarction (MI), stroke, and all-cause mortality during follow-up were analyzed according to three groups categorized by the presence of type 2 diabetes and insulin use. Results Within a mean 7.8 years, there were 5,275 MIs, 7,220 strokes, and 15,834 deaths. The hazards for outcomes were higher in the insulin-treated type 2 diabetes group than in the non-diabetes group [HR (95% CI): 2.344 (1.870-2.938) for MI, 2.420 (1.993-2.937) for stroke, and 3.037 (2.706-3.407) for death], higher in the non-insulin-treated type 2 diabetes group than in the non-diabetes group [HR (95% CI): 1.284 (1.159-1.423) for MI, 1.435 (1.320-1.561) for stroke, and 1.135 (1.067-1.206) for death], and higher in the insulin-treated type 2 diabetes group than in the non-insulin-treated type 2 diabetes group [HR (95% CI): 1.914 (1.502-2.441) for MI, 1.676 (1.363-2.060) for stroke, and 2.535 (2.232-2.880) for death]. Conclusions Recently diagnosed type 2 diabetes patients showed increased risks of incident CVDs and premature mortality, and insulin-treated group demonstrated an additional increase in the risks of these outcomes in adults with recently diagnosed type 2 diabetes, suggesting the need for intensified cardio-protective interventions for adults with insulin-treated type 2 diabetes.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - ETC > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.