High Bodyweight Variability Increases Depression Risk in Patients With Type 2 Diabetes Mellitus: A Nationwide Cohort Study in Korea
- Authors
- An, Ji Hyun; Han, Kyung-do; Jung, Jin-Hyung; Yoo, Juhwan; Fava, Maurizio; Mischoulon, David; Jung, Su-Min; Shin, Dong Wook; Hur, Kyu Yeon; Jeon, Hong Jin
- Issue Date
- 10-Dec-2021
- Publisher
- FRONTIERS MEDIA SA
- Keywords
- diabetes mellitus; depression; body weight variability; nationwide; body weight
- Citation
- FRONTIERS IN PSYCHIATRY, v.12
- Journal Title
- FRONTIERS IN PSYCHIATRY
- Volume
- 12
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/41955
- DOI
- 10.3389/fpsyt.2021.765129
- ISSN
- 1664-0640
- Abstract
- Objectives: Although obesity is associated with increased risk for depression in patients with type 2 diabetes mellitus (DM), the relationship between body weight variability (BWV) and depression remains poorly studied. This study was to investigate the incidence of depression in patients with type 2 DM according to their BWV.Methods: Intraindividual variation in body weight were measured in the nationwide, population-based retrospective cohort of 540,293 patients with type 2 DM from the Korean national health insurance system between 2009 and 2010. The diagnoses of new-onset depression occurring until the end of 2017 were ascertained. Risk of new-onset depression was examined using multivariate-adjusted Cox proportional hazards regression analysis by BWV quartile.Results: 93,149 (17.2%) patients developed new-onset depression for the follow up. BWV was significantly associated with an increased risk of depression after adjusting for confounding factors. The highest BWV quartile group had a hazard ratio (HR) of 1.17 (95% CI 1.15-1.19) compared to the lowest BWV quartile group as a reference. Obese patients in the highest BWV quartile group showed 12% increased risk of depression (HR 1.12, 95% CI 1.09-1.15) while non-obese patients in the highest BWV quartile group showed 20% increased risk of depression (HR: 1.20, 95% CI: 1.17-1.23) compared to their respective lowest BWV quartile groups.Conclusion: A higher BWV was significantly associated with an increased risk of depression in patients with type 2 DM. Thus, BWV may serve as an indicator for early detection of depression in type 2 DM patients.
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