Fibroblast activation protein activated antifibrotic peptide delivery attenuates fibrosis in mouse models of liver fibrosis
DC Field | Value | Language |
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dc.contributor.author | Lee, Jaiwoo | - |
dc.contributor.author | Byun, Junho | - |
dc.contributor.author | Shim, Gayong | - |
dc.contributor.author | Oh, Yu-Kyoung | - |
dc.date.accessioned | 2022-04-13T01:40:28Z | - |
dc.date.available | 2022-04-13T01:40:28Z | - |
dc.date.created | 2022-04-13 | - |
dc.date.issued | 2022-03-21 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/42126 | - |
dc.description.abstract | In liver fibrosis, activated hepatic stellate cells are known to overexpress fibroblast activation protein. Here we report a targeted anti-fibrotic peptide-delivery system in which fibroblast activation protein, which is overexpressed in fibrotic regions of the liver, liberates the antifibrotic peptide melittin by cleaving a fibroblast activation protein-specific site in the peptide. The promelittin peptide is linked to pegylated and maleimide-functionalized liposomes, resulting in promelittin-modified liposomes. The promelittin-modified liposomes were effective in reducing the viability of activated hepatic stellate cells but not that of control cells. In three types of liver fibrosis mouse models, intravenously administered promelittin-modified liposomes significantly reduces fibrotic regions. In addition, in the bile duct ligation mouse model promelittin-modified liposome-treatment increases overall survival. Although this peptide-delivery concept was tested for liver fibrosis, it can potentially be adapted to other fibrotic diseases. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.title | Fibroblast activation protein activated antifibrotic peptide delivery attenuates fibrosis in mouse models of liver fibrosis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41467-022-29186-8 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.13, no.1 | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000771678500033 | - |
dc.identifier.scopusid | 2-s2.0-85126887468 | - |
dc.citation.number | 1 | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 13 | - |
dc.contributor.affiliatedAuthor | Shim, Gayong | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordPlus | HEPATIC STELLATE CELLS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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