Sustained-Release Drug Delivery Potential of Antibiotic-Montmorillonite Composites Prepared Using Montmorillonite Mined in Gampo, Republic of Korea
DC Field | Value | Language |
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dc.contributor.author | Kim, Myungjae | - |
dc.contributor.author | Roh, Ki-Min | - |
dc.contributor.author | Kim, Jiwoo | - |
dc.contributor.author | Seo, Minkyeong | - |
dc.contributor.author | Kang, Il-Mo | - |
dc.contributor.author | Kim, Jiwoong | - |
dc.date.accessioned | 2022-05-12T02:40:04Z | - |
dc.date.available | 2022-05-12T02:40:04Z | - |
dc.date.created | 2022-03-08 | - |
dc.date.issued | 2022-02 | - |
dc.identifier.issn | 0009-8604 | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/42350 | - |
dc.description.abstract | Biocompatible drug-delivery materials are important because they provide controlled release of biologically active agents to enhance the effectiveness of medical treatments. Montmorillonite (Mnt) has been utilized in drug-delivery systems for delayed-release application because it can safely encapsulate drug molecules via intercalation reactions. The objective of the present study was to evaluate the delivery characteristics of the drug ciprofloxacin (CIP) from a composite with Mnt (Mnt-CIP) in which the Mnt was first prepared by acid treatment and vibration ball milling. The surfaces of Mnt were modified by reacting the Mnt suspension in 1.0 M HCl acid and by dispersing the powder with a vibration ball mill, then the CIP drug was added at pH 4 and stirred. The goal was to improve the sustained-release performance of the CIP. This Mnt-CIP drug-release system was characterized by X-ray diffraction, X-ray fluorescence analysis, Fourier-transform infrared spectroscopy, surface area measurement using the Brunauer-Emmett-Teller (BET) method, and ultraviolet spectroscopy. The X-ray diffraction results confirmed the intercalation of CIP into the interlayer space of Mnt. The in vitro release properties of the intercalated CIP were investigated using a simulated phosphate-buffered saline solution (pH 7.4) at 36 +/- 0.5 degrees C. The CIP drug exhibited a continued release for 3 h. Moreover, Mnt prepared by HCl acid treatment and dispersion in the vibration ball mill delayed the drug dissolution rate. In summary, the Mnt-CIP composite prepared in this study exhibited slow and sustained release characteristics, indicating that Mnt mined from the Gampo-40 mining area in Gyeongju can be used in various drug-delivery applications. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.relation.isPartOf | CLAYS AND CLAY MINERALS | - |
dc.title | Sustained-Release Drug Delivery Potential of Antibiotic-Montmorillonite Composites Prepared Using Montmorillonite Mined in Gampo, Republic of Korea | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s42860-022-00172-x | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | CLAYS AND CLAY MINERALS, v.70, no.1, pp.62 - 71 | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000760033200001 | - |
dc.identifier.scopusid | 2-s2.0-85125057611 | - |
dc.citation.endPage | 71 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 62 | - |
dc.citation.title | CLAYS AND CLAY MINERALS | - |
dc.citation.volume | 70 | - |
dc.contributor.affiliatedAuthor | Kim, Jiwoong | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordAuthor | Acid treatment | - |
dc.subject.keywordAuthor | Vibratory ball mill | - |
dc.subject.keywordAuthor | Ciprofloxacin | - |
dc.subject.keywordAuthor | Drug delivery | - |
dc.subject.keywordAuthor | Montmorillonite | - |
dc.subject.keywordAuthor | Sustained release | - |
dc.subject.keywordPlus | CLAY-MINERALS | - |
dc.subject.keywordPlus | SYSTEM INTERCALATION | - |
dc.subject.keywordPlus | CRYSTAL-STRUCTURE | - |
dc.subject.keywordPlus | ACID TREATMENT | - |
dc.subject.keywordPlus | CIPROFLOXACIN | - |
dc.subject.keywordPlus | NANOCOMPOSITE | - |
dc.subject.keywordPlus | ADSORPTION | - |
dc.subject.keywordPlus | CHARGE | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Geology | - |
dc.relation.journalResearchArea | Mineralogy | - |
dc.relation.journalResearchArea | Agriculture | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Geosciences, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Mineralogy | - |
dc.relation.journalWebOfScienceCategory | Soil Science | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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