Global profiling of RNA-chromatin interactions reveals co-regulatory gene expression networks in Arabidopsis
DC Field | Value | Language |
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dc.contributor.author | Li, Lanxia | - |
dc.contributor.author | Luo, Haofei | - |
dc.contributor.author | Lim, Do-Hwan | - |
dc.contributor.author | Han, Lu | - |
dc.contributor.author | Li, Yan | - |
dc.contributor.author | Fu, Xiang-Dong | - |
dc.contributor.author | Qi, Yijun | - |
dc.date.accessioned | 2022-05-23T06:40:04Z | - |
dc.date.available | 2022-05-23T06:40:04Z | - |
dc.date.created | 2022-05-23 | - |
dc.date.issued | 2021-10 | - |
dc.identifier.issn | 2055-026X | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/42367 | - |
dc.description.abstract | It is increasingly evident that various RNAs can bind chromatin to regulate gene expression and genome organization. Here we adapted a sequencing-based technique to profile RNA-chromatin interactions at a genome-wide scale in Arabidopsis seedlings. We identified more than 10,000 RNA-chromatin interactions mediated by protein-coding RNAs and non-coding RNAs. Cis and intra-chromosomal interactions are mainly mediated by protein-coding RNAs, whereas inter-chromosomal interactions are primarily mediated by non-coding RNAs. Many RNA-chromatin interactions tend to positively correlate with DNA-DNA interactions, suggesting their mutual influence and reinforcement. We further show that some RNA-chromatin interactions undergo alterations in response to biotic and abiotic stresses and that altered RNA-chromatin interactions form co-regulatory networks. Our study provides a global view on RNA-chromatin interactions in Arabidopsis and a rich resource for future investigations of regulatory roles of RNAs in gene expression and genome organization. Genome-wide profiles of RNA-chromatin interactions in Arabidopsis reveal the types of RNAs that mediate cis, intra-chromosomal and inter-chromosomal interactions and suggest the formation of co-regulatory gene expression networks in response to stresses. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.relation.isPartOf | NATURE PLANTS | - |
dc.title | Global profiling of RNA-chromatin interactions reveals co-regulatory gene expression networks in Arabidopsis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41477-021-01004-x | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | NATURE PLANTS, v.7, no.10, pp.1364 - + | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000707347100009 | - |
dc.citation.endPage | + | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1364 | - |
dc.citation.title | NATURE PLANTS | - |
dc.citation.volume | 7 | - |
dc.contributor.affiliatedAuthor | Lim, Do-Hwan | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordPlus | GENOME-WIDE ANALYSIS | - |
dc.subject.keywordPlus | LONG NONCODING RNAS | - |
dc.subject.keywordPlus | ANTISENSE TRANSCRIPTS | - |
dc.subject.keywordPlus | HEAT-STRESS | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | THALIANA | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | CHROMOCENTERS | - |
dc.subject.keywordPlus | NUCLEOLUS | - |
dc.subject.keywordPlus | DEFENSE | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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