Smoking and Periodontitis Can Play a Synergistic Role in the Development of Psoriasis: A Nationwide Cohort Study
- Authors
- Han, Ju Hee; Park, Jin Woo; Do Han, Kyung; Park, Jun Beom; Kim, Miri; Lee, Ji Hyun
- Issue Date
- May-2022
- Publisher
- KARGER
- Keywords
- Epidemiology; Periodontitis; Prevalence; Psoriasis; Smoking
- Citation
- DERMATOLOGY, v.238, no.3, pp.554 - 561
- Journal Title
- DERMATOLOGY
- Volume
- 238
- Number
- 3
- Start Page
- 554
- End Page
- 561
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/42763
- DOI
- 10.1159/000518296
- ISSN
- 1018-8665
- Abstract
- Background: Periodontitis is a chronic inflammatory disorder involving the periodontium. The precise nature of the association between periodontitis and psoriasis has not been determined. Objective: This nationwide population-based study investigated the relationship between periodontitis and the risk of psoriasis. Methods: A health screening database, which is a sub-dataset of the Korean National Health Insurance System database, was used in this study. Subjects with (n = 1,063,004) and without (n = 8,655,587) periodontitis who underwent health examinations from January to December 2009 were followed for 9 years. Results: In multivariable analysis, compared to the non-periodontitis group, periodontitis patients had a significantly higher risk of developing psoriasis (hazard ratio 1.116, 95% confidence interval 1.101-1.13). Non-smokers with periodontitis had an 11% increase in risk of psoriasis and smokers with periodontitis had a 26.5% increase in risk of psoriasis compared to non-smokers without periodontitis. Conclusion: Our study highlights periodontitis as a potential independent risk factor for psoriasis, increasing awareness of the synergistic role of smoking and periodontitis in the pathogenesis of psoriasis.
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