Low-Density Lipoprotein Cholesterol Level, Statin Use and Myocardial Infarction Risk in Young Adults
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정희경 | - |
dc.contributor.author | 한경도 | - |
dc.contributor.author | 유순집 | - |
dc.contributor.author | 김미경 | - |
dc.date.accessioned | 2022-12-15T05:40:08Z | - |
dc.date.available | 2022-12-15T05:40:08Z | - |
dc.date.created | 2022-12-05 | - |
dc.date.issued | 2022-09 | - |
dc.identifier.issn | 2287-2892 | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/42800 | - |
dc.description.abstract | Objective The consequences of blood lipid abnormalities for cardiovascular disease risk in young adults is unclear. Optimal lipid levels may also vary depending on whether a statin drug is taken. It aimed to determine whether the optimal lipid levels in young adults differ depending on statin use. Methods Using a nationally representative database from the Korean National Health Insurance System, 6,350,400 participants aged 20–39 years who underwent a health examination between 2009–2012 were followed through to 2018. The primary outcome was incident myocardial infarction (MI). We assessed the associations between prespecified lipid levels and MI risk according to statin use. Results Among participants not taking statins, low-density lipoprotein cholesterol (LDL-C) levels ≥120 mg/dL were significantly associated with MI risk (hazard ratio [HR], 1.33; 95% confidence interval [CI], 1.27–1.40) compared with statin nonusers with LDL-C <80 mg/dL. Statin users with LDL-C categories <80, 80–100, 100–120, and ≥120 mg/dL all had significantly higher MI risk compared with statin nonusers with LDL-C <80 mg/dL; these HRs (95% CIs) were 1.66 (1.39–1.99), 1.68 (1.36–2.09), 1.63 (1.31–2.02), and 2.32 (2.07–2.60), respectively. Conclusion Young adults taking statins have an increased MI risk compared with statin nonusers, even when they have similar LDL-C levels. Specific lipid targets may need to differ depending on statin use. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 한국지질동맥경화학회 | - |
dc.relation.isPartOf | 지질·동맥경화학회지 | - |
dc.title | Low-Density Lipoprotein Cholesterol Level, Statin Use and Myocardial Infarction Risk in Young Adults | - |
dc.title.alternative | Low-Density Lipoprotein Cholesterol Level, Statin Use and Myocardial Infarction Risk in Young Adults | - |
dc.type | Article | - |
dc.identifier.doi | 10.12997/jla.2022.11.3.288 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | 지질·동맥경화학회지, v.11, no.3, pp.288 - 298 | - |
dc.identifier.kciid | ART002877593 | - |
dc.description.journalClass | 1 | - |
dc.identifier.scopusid | 2-s2.0-85138497463 | - |
dc.citation.endPage | 298 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 288 | - |
dc.citation.title | 지질·동맥경화학회지 | - |
dc.citation.volume | 11 | - |
dc.contributor.affiliatedAuthor | 한경도 | - |
dc.identifier.url | https://e-jla.org/search.php?where=aview&id=10.12997/jla.2022.11.3.288&code=9992JLA&vmode=FULL | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordAuthor | Statin | - |
dc.subject.keywordAuthor | Cholesterol | - |
dc.subject.keywordAuthor | Cardiovascular disease | - |
dc.subject.keywordAuthor | Myocardial infarction | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Soongsil University Library 369 Sangdo-Ro, Dongjak-Gu, Seoul, Korea (06978)02-820-0733
COPYRIGHT ⓒ SOONGSIL UNIVERSITY, ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.