Blood-declustering excretable metal clusters assembled in DNA matrix
DC Field | Value | Language |
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dc.contributor.author | Lee, Jaiwoo | - |
dc.contributor.author | Le, Quoc-Viet | - |
dc.contributor.author | Ko, Seungbeom | - |
dc.contributor.author | Kang, Sungtaek | - |
dc.contributor.author | Macgregor, Robert B. | - |
dc.contributor.author | Shim, Gayong | - |
dc.contributor.author | Oh, Yu-Kyoung | - |
dc.date.accessioned | 2022-12-28T09:40:05Z | - |
dc.date.available | 2022-12-28T09:40:05Z | - |
dc.date.created | 2022-12-28 | - |
dc.date.issued | 2022-10 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/42958 | - |
dc.description.abstract | We report polymeric DNA-supported gold clusters that achieve interparticle plasmon-coupling, generate immunotherapeutic effects at the tumor tissue, but decluster in the bloodstream. As immunostimulating DNA, we used polyCpG DNA, which could act as a supporting matrix for metal clusters, enabling the clusters to decluster in the bloodstream. We constructed polyCpG-supported gold nanoclusters (AuPCN). For comparison with AuPCN, monomer CpG-bound gold nanoparticles (AuMC) were used. Unlike AuMC, AuPCN showed an inter-particle plasmon-coupling effect and a higher light-to heat conversion efficiency. In the serum, AuPCN declus-tered to subunits. The CT26 tumor rechallenge of mice pretreated with AuPCN(+NIR) was followed by 0% tumor recurrence and 100% survival for up to 80 days. Compared with other groups, AuPCN(+NIR)-treated mice revealed greater cytotoxic T cell-infiltration in distant tumors and higher memory T cells in the lymph nodes. Until 7 days post-dose, the urinary excretion of Au was observed in the AuPCN-treated group, but not in the Au nanoparticle-treated mice. Although we used gold clusters and concatemeric immunostimulatory CpG as com-ponents of AuPCN, the concept of declustering in the bloodstream can be applied to design other functional DNA scaffold-based metal clusters with reduced concerns for long-term retention in the body. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.relation.isPartOf | BIOMATERIALS | - |
dc.title | Blood-declustering excretable metal clusters assembled in DNA matrix | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.biomaterials.2022.121754 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, v.289 | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000855945200001 | - |
dc.identifier.scopusid | 2-s2.0-85137015384 | - |
dc.citation.title | BIOMATERIALS | - |
dc.citation.volume | 289 | - |
dc.contributor.affiliatedAuthor | Shim, Gayong | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0142961222003945?via%3Dihub | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordAuthor | Metal clusters | - |
dc.subject.keywordAuthor | Blood-declustering | - |
dc.subject.keywordAuthor | Excretable | - |
dc.subject.keywordAuthor | Kidney distribution | - |
dc.subject.keywordAuthor | Interparticle plasmon coupling effect | - |
dc.subject.keywordPlus | GOLD NANOPARTICLES | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | OXIDE | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | ANTIGEN | - |
dc.subject.keywordPlus | SIZE | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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