Association of comorbid mental disorders with cardiovascular disease risk in patients with type 2 diabetes: A nationwide cohort study
- Authors
- Kim, Hyewon; Lee, Kyu-Na; Shin, Dong Wook; Han, Kyungdo; Jeon, Hong Jin
- Issue Date
- Nov-2022
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- Type 2 diabetes; Cardiovascular diseases; Macrovascular complications; Mental disorder; Severe mental illness
- Citation
- GENERAL HOSPITAL PSYCHIATRY, v.79, pp.33 - 41
- Journal Title
- GENERAL HOSPITAL PSYCHIATRY
- Volume
- 79
- Start Page
- 33
- End Page
- 41
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/43455
- DOI
- 10.1016/j.genhosppsych.2022.10.005
- ISSN
- 0163-8343
- Abstract
- Objective: To examine the association between comorbid mental disorders and cardiovascular disease (CVD) risk among patients with type 2 diabetes. Method: This retrospective cohort study was conducted using the claims data of 2,227,394 South Korean patients with type 2 diabetes. We analyzed the occurrence of CVD including myocardial infarction (MI) and ischemic stroke, CVD-specific mortality, and all-cause mortality according to comorbid mental disorders including depressive disorders, bipolar and related disorders, schizophrenia spectrum disorders, insomnia, and anxiety disorders. Results: Among the patients, 9.1% had a comorbid mental disorder. The adjusted hazard ratios (aHR) for MI, ischemic stroke, CVD-specific mortality, and all-cause mortality in patients with any mental disorder were 1.20 (95% CI, 1.17-1.24), 1.13 (95% CI, 1.11-1.16), 1.16 (95% CI, 1.12-1.20), and 1.21 (95% CI, 1.19-1.23), respectively. Each mental disorder increased the risk of all outcomes, particularly bipolar and related disorders and schizophrenia spectrum disorders. Conclusion: Comorbid mental disorders increased the CVD risk in patients with type 2 diabetes, with significantly increased risks associated with schizophrenia spectrum disorders (aHR: 1.27 for MI and 1.50 for ischemic stroke) and bipolar and related disorders (aHR: 1.27 for MI and 1.45 for ischemic stroke).
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