Acromegaly and cardiovascular outcomes: a cohort study
DC Field | Value | Language |
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dc.contributor.author | Hong, Sangmo | - |
dc.contributor.author | Kim, Kyung-Soo | - |
dc.contributor.author | Han, Kyungdo | - |
dc.contributor.author | Park, Cheol-Young | - |
dc.date.accessioned | 2023-03-23T06:40:08Z | - |
dc.date.available | 2023-03-23T06:40:08Z | - |
dc.date.created | 2023-02-27 | - |
dc.date.issued | 2022-04 | - |
dc.identifier.issn | 0195-668X | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/43492 | - |
dc.description.abstract | Aims Cardiovascular disease is a common complication in acromegaly. We investigated the risk of cardiovascular disease and mortality in patients with acromegaly in a large-scale population using nationwide data in Korea. Methods and results We performed a nationwide, retrospective, observational, cohort study of patients with acromegaly (n = 1874) and age- and sex-matched subjects without acromegaly (n = 9370) for a mean follow-up of 7.5 +/- 3.2 years. The study outcomes were myocardial infarction, stroke, atrial fibrillation, congestive heart failure, and all-cause death. All outcomes were analysed by Cox proportional hazards regression analysis while controlling for age, sex, household income, place, Type 2 diabetes, hypertension, and dyslipidaemia. The incidence (per 1000 person-years) of atrial fibrillation (3.06 vs. 1.70; P = 0.001), congestive heart failure (3.11 vs. 1.63; P < 0.001), and all-cause mortality (6.31 vs. 4.03; P < 0.001) in patients with acromegaly was higher than in controls. However, the incidence of myocardial infarction and stroke did not differ between groups. After adjustment for covariates, the risk for atrial fibrillation [hazard ratio (HR): 1.59; 95% confidence interval (CI): 1.09-2.31], congestive heart failure (HR: 1.54; 95% CI: 1.06-2.25), and all-cause mortality (HR: 1.31; 95% CI: 1.01-1.69) was significantly higher in patients with acromegaly. In time lag sensitivity analysis, a higher risk for atrial fibrillation was observed only in the first 4 years after diagnosis in acromegaly patients compared with controls (HR: 3.05; 95% CI: 1.94-4.79). Conclusion Patients with acromegaly were at higher risk for atrial fibrillation, congestive heart failure, and all-cause death. The risk of atrial fibrillation had a time-dependent association with acromegaly. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.relation.isPartOf | EUROPEAN HEART JOURNAL | - |
dc.title | Acromegaly and cardiovascular outcomes: a cohort study | - |
dc.type | Article | - |
dc.identifier.doi | 10.1093/eurheartj/ehab822 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | EUROPEAN HEART JOURNAL, v.43, no.15, pp.1491 - 1499 | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000782480900011 | - |
dc.identifier.scopusid | 2-s2.0-85128489245 | - |
dc.citation.endPage | 1499 | - |
dc.citation.number | 15 | - |
dc.citation.startPage | 1491 | - |
dc.citation.title | EUROPEAN HEART JOURNAL | - |
dc.citation.volume | 43 | - |
dc.contributor.affiliatedAuthor | Han, Kyungdo | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordAuthor | Acromegaly | - |
dc.subject.keywordAuthor | Atrial fibrillation | - |
dc.subject.keywordAuthor | Congestive heart failure | - |
dc.subject.keywordAuthor | Mortality | - |
dc.subject.keywordAuthor | Myocardial infarction | - |
dc.subject.keywordAuthor | Stroke | - |
dc.subject.keywordPlus | GROWTH-HORMONE | - |
dc.subject.keywordPlus | MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | SOMATOSTATIN ANALOGS | - |
dc.subject.keywordPlus | ATRIAL-FIBRILLATION | - |
dc.subject.keywordPlus | IGF-I | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | HEART | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | COMORBIDITIES | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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