Association between History of Pregnancy and Liver Fibrosis Using Fibrosis-4 Index in Korean Postmenopausal Women: A Nationwide Population-Based Studyopen access
- Authors
- Ahn, Jae-Joon; Park, Joo-Hyun; Kim, Do-Hoon; Kim, Hyun-Jin; Ko, Hyung-Seok; Kwon, Jun-Yeon; Koh, Young-Sang; Jung, Jin-Hyung; Lee, Gyu-Na; Han, Kyungdo
- Issue Date
- Nov-2022
- Publisher
- KOREAN ACAD FAMILY MEDICINE
- Keywords
- Pregnancy; Liver Cirrhosis; Post-Menopause; Women; Reproductive History
- Citation
- KOREAN JOURNAL OF FAMILY MEDICINE, v.43, no.6, pp.388 - 395
- Journal Title
- KOREAN JOURNAL OF FAMILY MEDICINE
- Volume
- 43
- Number
- 6
- Start Page
- 388
- End Page
- 395
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/43497
- DOI
- 10.4082/kjfm.21.0177
- ISSN
- 2005-6443
- Abstract
- Background: The association between a history of pregnancy and liver fibrosis remains unclear. Herein, we investi-gated the association between reproductive factors, including a history of pregnancy and liver fibrosis, in post-menopausal Korean women.Methods: This study used nationally representative, population-based data collected from the Korea National Health and Nutrition Examination Survey 2008-2017. Of 14,624 women with natural menopause, 11,085 with no previous history of any type of cancer, hepatitis, or chronic heavy alcohol consumption were enrolled. We investi-gated the reproductive factors, including a history of pregnancy, total reproductive years, age at menarche and menopause, and oral contraceptive use. Liver fibrosis was defined as a Fibrosis-4 index score >= 2.67 kg/m2.Results: Of the study participants, 372 (3.3%) had advanced liver fibrosis. Multivariable logistic regression analysis showed that women with a history of more than one pregnancy were associated with a lower risk of liver fibrosis compared to women who had never been pregnant, after adjusting for potential confounders (adjusted odds ratio, 0.30; 95% confidence interval, 0.15-0.59). The risk of liver fibrosis did not increase significantly with an increasing number of pregnancies (P for trend=0.135). Other reproductive factors, including total reproductive years, age at menopause and menarche, and oral contraceptive use, were not significantly associated with liver fibrosis.Conclusion: Postmenopausal women who had experienced one or more pregnancies had a reduced risk of liver fi-brosis. Our findings reveal a potential protective role of pregnancy against liver fibrosis.
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