Cumulative Exposure to High gamma-Glutamyl Transferase Level and Risk of Diabetes: A Nationwide Population-Based Study
DC Field | Value | Language |
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dc.contributor.author | Park, Ji-Yeon | - |
dc.contributor.author | Han, Kyungdo | - |
dc.contributor.author | Kim, Hun-Sung | - |
dc.contributor.author | Cho, Jae-Hyoung | - |
dc.contributor.author | Yoon, Kun-Ho | - |
dc.contributor.author | Kim, Mee Kyoung | - |
dc.contributor.author | Lee, Seung-Hwan | - |
dc.date.accessioned | 2023-03-24T02:40:15Z | - |
dc.date.available | 2023-03-24T02:40:15Z | - |
dc.date.created | 2023-02-27 | - |
dc.date.issued | 2022-04 | - |
dc.identifier.issn | 2093-596X | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/43545 | - |
dc.description.abstract | Background: Elevated gamma-glutamyl transferase (gamma-GTP) level is associated with metabolic syndrome, impaired glucose tolerance, and insulin resistance, which are risk factors for type 2 diabetes. We aimed to investigate the association of cumulative exposure to high gamma-GTP level with risk of diabetes. Methods: Using nationally representative data from the Korean National Health Insurance system, 346,206 people who were free of diabetes and who underwent 5 consecutive health examinations from 2005 to 2009 were followed to the end of 2018. High gamma-GTP level was defined as those in the highest quartile, and the number of exposures to high gamma-GTP level ranged from 0 to 5. Hazard ratio (HR) and 95% confidence interval (CI) for diabetes were analyzed using the multivariable Cox proportional-hazards model. Results: The mean follow-up duration was 9.2 +/- 1.0 years, during which 15,183 (4.4%) patients developed diabetes. There was a linear increase in the incidence rate and the risk of diabetes with cumulative exposure to high gamma-GTP level. After adjusting for possible confounders, the HR of diabetes in subjects with five consecutive high gamma-GTP levels were 2.60 (95% CI, 2.47 to 2.73) in men and 3.05 (95% CI, 2.73 to 3.41) in women compared with those who never had a high gamma-GTP level. Similar results were observed in various subgroup and sensitivity analyses. Conclusion: There was a linear relationship between cumulative exposure to high gamma-GTP level and risk of diabetes. Monitoring and lowering gamma-GTP level should be considered for prevention of diabetes in the general population. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ENDOCRINE SOC | - |
dc.relation.isPartOf | ENDOCRINOLOGY AND METABOLISM | - |
dc.title | Cumulative Exposure to High gamma-Glutamyl Transferase Level and Risk of Diabetes: A Nationwide Population-Based Study | - |
dc.type | Article | - |
dc.identifier.doi | 10.3803/EnM.2022.1416 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | ENDOCRINOLOGY AND METABOLISM, v.37, no.2, pp.272 - 280 | - |
dc.identifier.kciid | ART002834859 | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000792399100010 | - |
dc.identifier.scopusid | 2-s2.0-85137356195 | - |
dc.citation.endPage | 280 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 272 | - |
dc.citation.title | ENDOCRINOLOGY AND METABOLISM | - |
dc.citation.volume | 37 | - |
dc.contributor.affiliatedAuthor | Han, Kyungdo | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordAuthor | Diabetes mellitus | - |
dc.subject.keywordAuthor | Gamma-glutamyltransferase | - |
dc.subject.keywordAuthor | Risk | - |
dc.subject.keywordPlus | FATTY LIVER-DISEASE | - |
dc.subject.keywordPlus | INDEPENDENT PREDICTOR | - |
dc.subject.keywordPlus | METABOLIC SYNDROME | - |
dc.subject.keywordPlus | HEALTH-INSURANCE | - |
dc.subject.keywordPlus | TYPE-2 | - |
dc.subject.keywordPlus | MELLITUS | - |
dc.subject.keywordPlus | WOMEN | - |
dc.subject.keywordPlus | MEN | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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