Increased incidence of leukemia in patients with obstructive sleep apnea: Results from the national insurance claim data 2007-2014
- Authors
- Lee, Eun Jung; Do Han, Kyung; Kim, Sung-Yong; Suh, Jeffrey D.; Kim, Jin Kook; Cho, Jae Hoon
- Issue Date
- Aug-2022
- Publisher
- ELSEVIER
- Keywords
- Obstructive sleep apnea; Leukemia; Lymphoid type
- Citation
- SLEEP MEDICINE, v.96, pp.113 - 118
- Journal Title
- SLEEP MEDICINE
- Volume
- 96
- Start Page
- 113
- End Page
- 118
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/43587
- DOI
- 10.1016/j.sleep.2022.05.009
- ISSN
- 1389-9457
- Abstract
- Purpose: Prior research suggests a link between obstructive sleep apnea (OSA) and the likelihood of developing a variety of solid tumors; however, there are no studies assessing OSA and leukemia. This study is the first to identify a potential association between OSA and leukemia using data from the Korea National Health Insurance Service database. Methods: A total of 162,646 patients (>= 20 years of age and without any cancer history) newly diagnosed with OSA between 2011 and 2017 were included. A control group of 813,230 subjects was selected using propensity score matching based on age and sex. The mean follow-up time was 4.4 +/- 2.0 years. The primary endpoint was newly diagnosed leukemia of any type. The leukemia hazard ratio (95% confidence interval [CI]) was calculated for patients with OSA and compared with that of patients in the control group. Results: The incidence of leukemia among patients with OSA was significantly higher than that in the controls (1.35 [1.05-1.74]). The hazard ratio was the highest, 1.74 in those under 40 years, and gradually decreased with age, to 1.38 in those aged 40-65 years and 0.96 in those over 65. In particular, the incidence of lymphoid leukemia (2.06 [1.18-3.60]) was higher than that of myeloid (1.34 [1.00-1.81]) or unspecified leukemia (0.60 [0.20-1.58]). Conclusion: OSA is associated with an increased incidence of leukemia, particularly in patients younger than 40 years of age. (C) 2022 Elsevier B.V. All rights reserved.
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