Impact of diabetes mellitus on the outcomes of subjects with hypertrophic cardiomyopathy: A nationwide cohort study
DC Field | Value | Language |
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dc.contributor.author | Lee, Hyun-Jung | - |
dc.contributor.author | Kim, Hyung-Kwan | - |
dc.contributor.author | Kim, Bong-Seong | - |
dc.contributor.author | Han, Kyung-Do | - |
dc.contributor.author | Rhee, Tae-Min | - |
dc.contributor.author | Park, Jun-Bean | - |
dc.contributor.author | Lee, Heesun | - |
dc.contributor.author | Lee, Seung-Pyo | - |
dc.contributor.author | Kim, Yong-Jin | - |
dc.date.accessioned | 2023-03-28T02:40:13Z | - |
dc.date.available | 2023-03-28T02:40:13Z | - |
dc.date.created | 2023-02-27 | - |
dc.date.issued | 2022-04 | - |
dc.identifier.issn | 0168-8227 | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/43652 | - |
dc.description.abstract | Aims: Diabetes mellitus (DM) often coexists in elderly hypertrophic cardiomyopathy (HCM) patients; however, its impact on clinical outcomes is unclear. Methods: We compared clinical outcomes according to the presence of DM in a nationwide HCM cohort. Results: In 9,883 HCM subjects (mean age 58.5 +/- 13.1, men 71.7%), 1,327 (13.4%) had DM. During follow-up (mean 5.9 +/- 2.5 years), end-stage renal disease (ESRD) progression, coronary events (myocardial infarction, coronary revascularization), heart failure (HF), cardiovascular mortality, and all-cause mortality occurred in 80 (0.8%), 365 (3.7%), 1,558 (15.8%), 354 (3.6%), and 877 (8.9%) subjects, respectively. DM HCM subjects had significantly higher risks of ESRD progression (HR 3.49, 95% CI 2.20-5.54) and HF (HR 1.15, 95% CI 1.01-1.32) compared to non-DM HCM subjects, independent of age, sex, ischemic heart disease, atrial fibrillation, and other comorbidities. There was a tendency for greater risk of ESRD progression, HF, and all-cause death in subjects with more advanced stage of DM (p-for-trend < 0.05 for all). Insulin-treated DM was associated with the highest risk. Conclusions: DM HCM subjects have higher risk of ESRD progression and HF. Considering the extended life expectancy of HCM and increasing number of elderly HCM subjects, active surveillance and management of DM-related outcomes should be highlighted. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.relation.isPartOf | DIABETES RESEARCH AND CLINICAL PRACTICE | - |
dc.title | Impact of diabetes mellitus on the outcomes of subjects with hypertrophic cardiomyopathy: A nationwide cohort study | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.diabres.2022.109838 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | DIABETES RESEARCH AND CLINICAL PRACTICE, v.186 | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000803883000028 | - |
dc.identifier.scopusid | 2-s2.0-85126718239 | - |
dc.citation.title | DIABETES RESEARCH AND CLINICAL PRACTICE | - |
dc.citation.volume | 186 | - |
dc.contributor.affiliatedAuthor | Han, Kyung-Do | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordAuthor | Hypertrophic cardiomyopathy | - |
dc.subject.keywordAuthor | Diabetes mellitus | - |
dc.subject.keywordAuthor | Diabetes Complications | - |
dc.subject.keywordAuthor | Heart failure | - |
dc.subject.keywordAuthor | Diabetic Cardiomyopathies | - |
dc.subject.keywordAuthor | Outcomes | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | HEART | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | FIBROSIS | - |
dc.subject.keywordPlus | KIDNEY | - |
dc.subject.keywordPlus | WOMEN | - |
dc.subject.keywordPlus | MEN | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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