CMOS electrochemical pH localizer-imageropen access
- Authors
- Jung, Han Sae; Jung, Woo-Bin; Wang, Jun; Abbott, Jeffrey; Horgan, Adrian; Fournier, Maxime; Hinton, Henry; Hwang, Young-Ha; Godron, Xavier; Nicol, Robert; Park, Hongkun; Ham, Donhee
- Issue Date
- Jul-2022
- Publisher
- AMER ASSOC ADVANCEMENT SCIENCE
- Citation
- SCIENCE ADVANCES, v.8, no.30
- Journal Title
- SCIENCE ADVANCES
- Volume
- 8
- Number
- 30
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/43771
- DOI
- 10.1126/sciadv.abm6815
- ISSN
- 2375-2548
- Abstract
- pH controls a large repertoire of chemical and biochemical processes in water. Densely arrayed pH microenvironments would parallelize these processes, enabling their high-throughput studies and applications. However, pH localization, let alone its arrayed realization, remains challenging because of fast diffusion of protons in water. Here, we demonstrate arrayed localizations of picoliter-scale aqueous acids, using a 256-electrochemical cell array defined on and operated by a complementary metal oxide semiconductor (CMOS)-integrated circuit. Each cell, comprising a concentric pair of cathode and anode with their current injections controlled with a sub-nanoampere resolution by the CMOS electronics, creates a local pH environment, or a pH "voxel," via confined electrochemistry. The system also monitors the spatiotemporal pH profile across the array in real time for precision pH control. We highlight the utility of this CMOS pH localizer-imager for high-throughput tasks by parallelizing pH-gated molecular state encoding and pH-regulated enzymatic DNA elongation at any selected set of cells.
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