Association Between Metabolic Syndrome and Risk of Esophageal Cancer: a Nationwide Population-Based Study
DC Field | Value | Language |
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dc.contributor.author | Lee, Ji Eun | - |
dc.contributor.author | Han, Kyungdo | - |
dc.contributor.author | Yoo, Juhwan | - |
dc.contributor.author | Yeo, Yohwan | - |
dc.contributor.author | Cho, In Young | - |
dc.contributor.author | Cho, Belong | - |
dc.contributor.author | Park, Jin-Ho | - |
dc.contributor.author | Shin, Dong Wook | - |
dc.contributor.author | Cho, Jong Ho | - |
dc.contributor.author | Park, Yong -Moon | - |
dc.date.accessioned | 2023-04-17T03:40:04Z | - |
dc.date.available | 2023-04-17T03:40:04Z | - |
dc.date.created | 2023-02-27 | - |
dc.date.issued | 2022-12 | - |
dc.identifier.issn | 1055-9965 | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/43778 | - |
dc.description.abstract | Background: Metabolic syndrome (MetS) is believed to increase the risk of esophageal cancer. However, most studies have been conducted in Western countries, focusing on esophageal adeno-carcinoma (EAC). We aimed to investigate the association between MetS and risk of esophageal cancer in nationally representative large dataset in Korea, where esophageal squamous cell carcinoma (ESCC) is predominant.Methods: We analyzed the health examinations and claims data from the Korean National Health Insurance Service (NHIS). A total of 6,795,738 subjects who received an NHIS provided health examination in 2009 (index year) were included. Cox proportional hazards models were used to estimate multi -variable adjusted HRs (aHR) and 95% confidence intervals (CI) for the association of MetS and its components (elevated waist circumference, blood pressure, triglycerides, fasting blood glucose, reduced high-density lipoprotein cholesterol) with the risk of esophageal cancer.Results: During a mean (+/- SD) follow-up of 8.2 (+/- 1.1) years, 6,414 cases of esophageal cancer occurred. MetS was associated with an increased risk of esophageal cancer (aHR, 1.11; 95% CI, 1.05- 1.18). Among the components of MetS, elevated waist circumfer-ence (aHR, 1.24; 95% CI, 1.16-1.33), high blood pressure (aHR, 1.29; 95% CI, 1.22-1.37), and fasting blood glucose (aHR, 1.16; 95% CI, 1.11-1.22) were associated with increased risk of esophageal cancer.Conclusions: MetS was associated with an increased risk of esophageal cancer.Impact: Our findings suggest that individuals with MetS may be at increased risk for esophageal cancer, specifically ESCC. Further studies are needed to establish the relationship between MetS and esophageal cancer. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER ASSOC CANCER RESEARCH | - |
dc.relation.isPartOf | CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | - |
dc.title | Association Between Metabolic Syndrome and Risk of Esophageal Cancer: a Nationwide Population-Based Study | - |
dc.type | Article | - |
dc.identifier.doi | 10.1158/1055-9965.EPI-22-0703 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, v.31, no.12, pp.2228 - 2236 | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000892741700001 | - |
dc.identifier.scopusid | 2-s2.0-85126439249 | - |
dc.citation.endPage | 2236 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 2228 | - |
dc.citation.title | CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | - |
dc.citation.volume | 31 | - |
dc.contributor.affiliatedAuthor | Han, Kyungdo | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordPlus | SQUAMOUS-CELL CARCINOMA | - |
dc.subject.keywordPlus | METABOLIC RISK-FACTORS | - |
dc.subject.keywordPlus | ESOPHAGEAL ADENOCARCINOMA | - |
dc.subject.keywordPlus | BARRETTS-ESOPHAGUS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | OBESITY | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Public, Environmental & Occupational Health | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Public, Environmental & Occupational Health | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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