Association between Low-Density Lipoprotein Cholesterol Level and Cardiovascular Outcomes in Korean Adults: A Nationwide Cohort Study
DC Field | Value | Language |
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dc.contributor.author | Noh, J. | - |
dc.contributor.author | Moon, M.K. | - |
dc.contributor.author | Rhee, E.-J. | - |
dc.contributor.author | Park, S.H. | - |
dc.contributor.author | Kim, H.C. | - |
dc.contributor.author | Kim, B.J. | - |
dc.contributor.author | Kim, H.J. | - |
dc.contributor.author | Choi, S. | - |
dc.contributor.author | Na, J.O. | - |
dc.contributor.author | Hyun, Y.Y. | - |
dc.contributor.author | Kim, B.J. | - |
dc.contributor.author | Han, K.-D. | - |
dc.contributor.author | Jeong, I.-K. | - |
dc.contributor.author | Committee of Practice Guideline of Korean Lipid and Atherosclerosis | - |
dc.date.accessioned | 2023-04-27T01:40:08Z | - |
dc.date.available | 2023-04-27T01:40:08Z | - |
dc.date.created | 2023-04-13 | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 2233-6079 | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/43793 | - |
dc.description.abstract | Background: To validate the treatment target of low-density lipoprotein cholesterol (LDL-C) level according to the cardiovascular disease (CVD) risk which was recommended by Korean dyslipidemia guideline. Methods: We used the Korean National Health Insurance Service database which included 3,958,048 people aged 20 to 89 years who underwent regular health screening. The primary outcome was incident CVD, defined as a composite of myocardial infarction and stroke during the follow-up period from 2009 to 2018. Results: The risk of CVD increased from LDL-C level of 70 mg/dL in very high-risk and high-risk groups and from 130 mg/dL in moderate-risk and low-risk groups. Adjusted hazard ratios (HRs) of LDL-C ranges 70-99, 100-129, 130-159, 160-189, and ≥190 mg/dL were 1.20 (95% confidence interval [CI], 1.08-1.33), 1.27 (1.15-1.42), 1.39 (1.23-1.56), 1.69 (1.45-1.96), and 1.84 (1.49-2.27) in very high-risk group, and 1.07 (1.02-1.13), 1.16 (1.10-1.21), 1.29 (1.22-1.36), 1.45 (1.36-1.55), and 1.73 (1.58-1.90) in high-risk group. Adjusted HRs (95% CI) of LDL-C ranges 130-159, 160-189, and ≥190 mg/dL were 1.15 (1.11-1.20), 1.28 (1.22-1.34), and 1.45 (1.36-1.54) in moderate-risk group and 1.07 (1.02-1.13), 1.20 (1.13-1.26), and 1.47 (1.37-1.57) in low-risk group. Conclusion: We confirmed the incidence of CVD was increased in higher LDL-C range. The risk of CVD increased from ≥70 mg/dL of LDL-C in very high-risk and high-risk groups, and from ≥130 mg/dL of LDL-C in moderate-risk and low-risk groups in Korean adults. Copyright © 2023 Korean Diabetes Association. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Korean Diabetes Association | - |
dc.relation.isPartOf | Diabetes and Metabolism Journal | - |
dc.title | Association between Low-Density Lipoprotein Cholesterol Level and Cardiovascular Outcomes in Korean Adults: A Nationwide Cohort Study | - |
dc.type | Article | - |
dc.identifier.doi | 10.4093/dmj.2021.0320 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Diabetes and Metabolism Journal, v.47, no.1, pp.59 - 71 | - |
dc.identifier.kciid | ART002926891 | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000931560600005 | - |
dc.identifier.scopusid | 2-s2.0-85147147783 | - |
dc.citation.endPage | 71 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 59 | - |
dc.citation.title | Diabetes and Metabolism Journal | - |
dc.citation.volume | 47 | - |
dc.contributor.affiliatedAuthor | Han, K.-D. | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordAuthor | Cardiovascular diseases | - |
dc.subject.keywordAuthor | Cholesterol | - |
dc.subject.keywordAuthor | Korea | - |
dc.subject.keywordAuthor | LDL | - |
dc.subject.keywordPlus | PRIMARY PREVENTION | - |
dc.subject.keywordPlus | ATORVASTATIN | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | STATIN | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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