Positive Results from the Fecal Immunochemical Test Can Be Related to Dementia: A Nationwide Population-Based Study in South Korea
- Authors
- Jun, Yu Kyung; Lee, Seung Woo; Kim, Kwang Woo; Moon, Jung Min; Koh, Seong-Joon; Lee, Hyun Jung; Kim, Joo Sung; Han, Kyungdo; Im, Jong Pil
- Issue Date
- Feb-2023
- Publisher
- IOS PRESS
- Keywords
- Alzheimer' s disease; dementia; occult blood; population surveillance; vascular dementia
- Citation
- JOURNAL OF ALZHEIMERS DISEASE, v.91, no.4, pp.1515 - 1525
- Journal Title
- JOURNAL OF ALZHEIMERS DISEASE
- Volume
- 91
- Number
- 4
- Start Page
- 1515
- End Page
- 1525
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/43860
- DOI
- 10.3233/JAD-220770
- ISSN
- 1387-2877
- Abstract
- Background: The fecal immunochemical test (FIT) is widely used in screening for colorectal cancer (CRC), but FIT results can be positive for diseases other than CRC. Objective: We investigated the association between positive results of FIT and the incidence of dementia using a nationwide database. Methods: FIT-positive participants were collected from a database provided by theKorean National Health Insurance Service. Results: The incidence of all kinds of dementia was higher in FIT-positive than FIT-negative subjects (p < 0.0001). FITpositive participants had a higher risk of Alzheimer's disease (AD) (p < 0.0001) and vascular dementia (p = 0.0002), compared to participants with FIT negativity. The risk of all kinds of dementia or AD in FIT-positive participants was higher in younger (age < 65 years) than older participants (p < 0.0001 for all kinds of dementia; p = 0.0002 for AD). Conclusion: FIT positivity was correlated with an increased risk of dementia, especially in participants under 65 years of age. The study suggests that clinicians can consider dementia when FIT-positive participants fail to show any malignancies.
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