Lysyl oxidase-responsive anchoring nanoparticles for modulation of the tumor immune microenvironment
DC Field | Value | Language |
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dc.contributor.author | Park, Jinwon | - |
dc.contributor.author | Kim, Jung Suk | - |
dc.contributor.author | Yang, Geon | - |
dc.contributor.author | Lee, Hobin | - |
dc.contributor.author | Shim, Gayong | - |
dc.contributor.author | Lee, Jaiwoo | - |
dc.contributor.author | Oh, Yu Kyoung | - |
dc.date.accessioned | 2023-09-05T04:40:05Z | - |
dc.date.available | 2023-09-05T04:40:05Z | - |
dc.date.created | 2023-09-04 | - |
dc.date.issued | 2023-08 | - |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/44236 | - |
dc.description.abstract | In the tumor microenvironment, lysyl oxidase (LOX) is known to play a key role in stabilizing the tumor extracellular matrix. Here, we designed LOX-responsive nanoparticles to interact with the collagen matrix of the tumor microenvironment. Collagen-coated and imiquimod-loaded polydopamine nanoparticles (CPN/IQ) could form crosslinked structures with the collagen matrix via LOX. In vitro, anchoring of CPN/IQ nanoparticles was observed with LOX-secreting CT26 cells, but this was blocked by a LOX inhibitor. In CT26 tumor-bearing mice, co-administration of nanoparticles plus the LOX inhibitor did not significantly alter the antitumor efficacy among nanoparticles. In the absence of the LOX inhibitor, however, a single administration of CPN/IQ could provide sustained responsiveness to near-infrared irradiation and ablation of primary tumors. In the primary tumor microenvironment, CPN/IQ lowered the Treg cell population but increased the cytotoxic CD3+CD8+ T cell population. In splenic dendritic cells, CPN/IQ treatment significantly increased the CD11c+CD86+ and CD11c+CD80+ cell populations. In a CT26 distant tumor-rechallenge model, CPN/IQ treatment increased the cytotoxic CD3+CD8+ T cell population and provided 100% survival of mice until 64 days. This study indicates the feasibility of tumor immune microenvironment modulation using LOX-responsive size-transforming nanoparticles. Although we tested the concept in a CT26 cell-derived tumor model, the concept of LOX-responsive collagen matrix- anchoring nanoparticles may be broadly applied to other tumor tissues with LOX-rich tumor microenvironments. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.relation.isPartOf | JOURNAL OF CONTROLLED RELEASE | - |
dc.title | Lysyl oxidase-responsive anchoring nanoparticles for modulation of the tumor immune microenvironment | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jconrel.2023.06.041 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF CONTROLLED RELEASE, v.360, pp.376 - 391 | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 001040296300001 | - |
dc.identifier.scopusid | 2-s2.0-85164213481 | - |
dc.citation.endPage | 391 | - |
dc.citation.startPage | 376 | - |
dc.citation.title | JOURNAL OF CONTROLLED RELEASE | - |
dc.citation.volume | 360 | - |
dc.contributor.affiliatedAuthor | Shim, Gayong | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0168365923004248?via%3Dihub | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordAuthor | Lysyl oxidase | - |
dc.subject.keywordAuthor | Extracellular matrix anchoring | - |
dc.subject.keywordAuthor | Collagen coating | - |
dc.subject.keywordAuthor | Tumor immune microenvironment | - |
dc.subject.keywordAuthor | Immunotherapy | - |
dc.subject.keywordPlus | POLYDOPAMINE | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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