MicroRNA miR-274-5p Suppresses Found-in-Neurons Associated with Melanotic Mass Formation and Developmental Growth in Drosophila
DC Field | Value | Language |
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dc.contributor.author | Kim, Hee Kyung | - |
dc.contributor.author | Kim, Chae Jeong | - |
dc.contributor.author | Jang, Daegyu | - |
dc.contributor.author | Lim, Do-Hwan | - |
dc.date.accessioned | 2023-09-21T03:40:04Z | - |
dc.date.available | 2023-09-21T03:40:04Z | - |
dc.date.created | 2023-09-15 | - |
dc.date.issued | 2023-08 | - |
dc.identifier.issn | 2075-4450 | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/44281 | - |
dc.description.abstract | The hematopoietic system plays a crucial role in immune defense response and normal development, and it is regulated by various factors from other tissues. The dysregulation of hematopoiesis is associated with melanotic mass formation; however, the molecular mechanisms underlying this process are poorly understood. Here, we observed that the overexpression of miR-274 in the fat body resulted in the formation of melanotic masses. Moreover, abnormal activation of the JNK and JAK/STAT signaling pathways was linked to these consequences. In addition to this defect, miR-274 overexpression in the larval fat body decreased the total tissue size, leading to a reduction in body weight. miR-274-5p was found to directly suppress the expression of found-in-neurons (fne), which encodes an RNA-binding protein. Similar to the effects of miR-274 overexpression, fne depletion led to melanotic mass formation and growth reduction. Collectively, miR-274 plays a regulatory role in the fne–JNK signaling axis in melanotic mass formation and growth control. © 2023 by the authors. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.relation.isPartOf | Insects | - |
dc.title | MicroRNA miR-274-5p Suppresses Found-in-Neurons Associated with Melanotic Mass Formation and Developmental Growth in Drosophila | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/insects14080709 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Insects, v.14, no.8 | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 001055271700001 | - |
dc.identifier.scopusid | 2-s2.0-85168999858 | - |
dc.citation.number | 8 | - |
dc.citation.title | Insects | - |
dc.citation.volume | 14 | - |
dc.contributor.affiliatedAuthor | Lim, Do-Hwan | - |
dc.identifier.url | https://www.mdpi.com/2075-4450/14/8/709 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordAuthor | Drosophila | - |
dc.subject.keywordAuthor | found-in-neurons | - |
dc.subject.keywordAuthor | growth | - |
dc.subject.keywordAuthor | JAK/STAT signaling | - |
dc.subject.keywordAuthor | JNK signaling | - |
dc.subject.keywordAuthor | melanotic mass | - |
dc.subject.keywordAuthor | miR-274 | - |
dc.subject.keywordPlus | BLOOD-CELLS | - |
dc.subject.keywordPlus | JAK/STAT | - |
dc.subject.keywordPlus | TARGETS | - |
dc.subject.keywordPlus | HOMEOSTASIS | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | HEMOCYTES | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | SIZE | - |
dc.relation.journalResearchArea | Entomology | - |
dc.relation.journalWebOfScienceCategory | Entomology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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