Near-sensor computing-assisted simultaneous viral antigen and antibody detection via integrated label-free biosensors with microfluidics
DC Field | Value | Language |
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dc.contributor.author | Bae, Byungjoon | - |
dc.contributor.author | Baek, Yongmin | - |
dc.contributor.author | Yang, Jeongyong | - |
dc.contributor.author | Lee, Heesung | - |
dc.contributor.author | Sonnadara, Charana S. S. | - |
dc.contributor.author | Jung, Sangeun | - |
dc.contributor.author | Park, Minseong | - |
dc.contributor.author | Lee, Doeon | - |
dc.contributor.author | Kim, Sihwan | - |
dc.contributor.author | Giri, Gaurav | - |
dc.contributor.author | Shah, Sahil | - |
dc.contributor.author | Yoo, Geonwook | - |
dc.contributor.author | Petri, William A. A. | - |
dc.contributor.author | Lee, Kyusang | - |
dc.date.accessioned | 2023-11-10T07:40:04Z | - |
dc.date.available | 2023-11-10T07:40:04Z | - |
dc.date.created | 2023-09-04 | - |
dc.date.issued | 2023-10 | - |
dc.identifier.issn | 2567-3165 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/44595 | - |
dc.description.abstract | Precise diagnosis and immunity to viruses, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Middle East respiratory syndrome coronavirus (MERS-CoV) is achieved by the detection of the viral antigens and/or corresponding antibodies, respectively. However, a widely used antigen detection methods, such as polymerase chain reaction (PCR), are complex, expensive, and time-consuming Furthermore, the antibody test that detects an asymptomatic infection and immunity is usually performed separately and exhibits relatively low accuracy. To achieve a simplified, rapid, and accurate diagnosis, we have demonstrated an indium gallium zinc oxide (IGZO)-based biosensor field-effect transistor (bio-FET) that can simultaneously detect spike proteins and antibodies with a limit of detection (LOD) of 1 pg mL(-1) and 200 ng mL(-1), respectively using a single assay in less than 20 min by integrating microfluidic channels and artificial neural networks (ANNs). The near-sensor ANN-aided classification provides high diagnosis accuracy (>93%) with significantly reduced processing time (0.62%) and energy consumption (5.64%) compared to the software-based ANN. We believe that the development of rapid and accurate diagnosis system for the viral antigens and antibodies detection will play a crucial role in preventing global viral outbreaks. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.relation.isPartOf | INFOMAT | - |
dc.title | Near-sensor computing-assisted simultaneous viral antigen and antibody detection via integrated label-free biosensors with microfluidics | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/inf2.12471 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | INFOMAT, v.5, no.10 | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 001040742500001 | - |
dc.identifier.scopusid | 2-s2.0-85166435836 | - |
dc.citation.number | 10 | - |
dc.citation.title | INFOMAT | - |
dc.citation.volume | 5 | - |
dc.contributor.affiliatedAuthor | Yoo, Geonwook | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/inf2.12471 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordAuthor | artificial intelligence | - |
dc.subject.keywordAuthor | biosensor | - |
dc.subject.keywordAuthor | edge-computing | - |
dc.subject.keywordAuthor | integration | - |
dc.subject.keywordAuthor | microfluidic | - |
dc.subject.keywordPlus | SILICON-OXIDE SURFACES | - |
dc.subject.keywordPlus | HIGH-PERFORMANCE | - |
dc.subject.keywordPlus | FIELD | - |
dc.subject.keywordPlus | SPECTROSCOPY | - |
dc.subject.keywordPlus | ATTACHMENT | - |
dc.subject.keywordPlus | STABILITY | - |
dc.subject.keywordPlus | APTES | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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