Optimal LDL cholesterol levels in young and old patients with type 2 diabetes for secondary prevention of cardiovascular diseases are different
DC Field | Value | Language |
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dc.contributor.author | Jeong, Chaiho | - |
dc.contributor.author | Kim, Bongseong | - |
dc.contributor.author | Kim, Jinyoung | - |
dc.contributor.author | Baek, Hansang | - |
dc.contributor.author | Kim, Mee Kyoung | - |
dc.contributor.author | Sohn, Tae-Seo | - |
dc.contributor.author | Baek, Ki-Hyun | - |
dc.contributor.author | Song, Ki-Ho | - |
dc.contributor.author | Son, Hyun-Shik | - |
dc.contributor.author | Han, Kyungdo | - |
dc.contributor.author | Kwon, Hyuk-Sang | - |
dc.date.accessioned | 2023-12-01T06:40:46Z | - |
dc.date.available | 2023-12-01T06:40:46Z | - |
dc.date.created | 2023-12-01 | - |
dc.date.issued | 2023-11 | - |
dc.identifier.issn | 2049-3614 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/44655 | - |
dc.description.abstract | Objective: Real-world-based population data about the optimal low-density lipoprotein cholesterol (LDL-C) level for preventing cardiovascular disease in very high-risk populations is scarce. Methods: From 2009 to 2012, 26,922 people aged >= 40 years with type 2 diabetes mellitus (T2DM) who had a history of percutaneous coronary intervention (PCI) were analyzed. Data from the Korean National Health Insurance System were used. They were followed up to the date of a cardiovascular event or the time to death, or until December 31, 2018. Endpoints were recurrent PCI, newly stroke or heart failure, cardiovascular death, and all-cause death. Participants were divided into the following categories according to LDL-C level: <55 mg/dL, 55-69 mg/dL, 70-99 mg/dL, 100-129 mg/dL, 130-159 mg/dL, and >= 160 mg/dL. Results: Compared to LDL-C < 55 mg/dL, the hazard ratios (HR) for re-PCI and stroke increased linearly with increasing LDL-C level in the population < 65 years. However, in >= 65 years old, HRs for re-PCI and stroke in LDL-C = 55-69 mg/dL were 0.97 (95% CI: 0.85-1.11) and 0.96 (95% CI: 0.79-2.23), respectively. The optimal range with the lowest HR for heart failure and all-cause mortality were LDL-C = 70-99 mg/dL and LDL-C = 55-69 mg/dL, respectively, in all age groups (HR: 0.99, 95% CI: 0.91-1.08 and HR: 0.91, 95% CI: 0.81-1.01). Conclusion: LDL-C level below 55 mg/dL appears to be optimal in T2DM patients with established cardiovascular disease aged < 65 years, while an LDL-C level of 55-69 mg/dL may be optimal for preventing recurrent PCI and stroke in patients over 65 years old. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BIOSCIENTIFICA LTD | - |
dc.relation.isPartOf | ENDOCRINE CONNECTIONS | - |
dc.title | Optimal LDL cholesterol levels in young and old patients with type 2 diabetes for secondary prevention of cardiovascular diseases are different | - |
dc.type | Article | - |
dc.identifier.doi | 10.1530/EC-23-0142 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | ENDOCRINE CONNECTIONS, v.12, no.11 | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 001094082100014 | - |
dc.identifier.scopusid | 2-s2.0-85173724201 | - |
dc.citation.number | 11 | - |
dc.citation.title | ENDOCRINE CONNECTIONS | - |
dc.citation.volume | 12 | - |
dc.contributor.affiliatedAuthor | Han, Kyungdo | - |
dc.identifier.url | https://ec.bioscientifica.com/view/journals/ec/12/11/EC-23-0142.xml | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordAuthor | type 2 diabetes mellitus | - |
dc.subject.keywordAuthor | LDL cholesterol | - |
dc.subject.keywordAuthor | diabetes complications | - |
dc.subject.keywordAuthor | cardiovascular diseases | - |
dc.subject.keywordPlus | DENSITY-LIPOPROTEIN CHOLESTEROL | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | SAFETY | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | PLASMA | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | THERAPY | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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