Risk of Pancreatic Cancer and Use of Dipeptidyl Peptidase 4 Inhibitors in Patients with Type 2 Diabetes: A Propensity Score-Matching Analysis
DC Field | Value | Language |
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dc.contributor.author | Kim, Mee Kyoung | - |
dc.contributor.author | Han, Kyungdo | - |
dc.contributor.author | Kwon, Hyuk-Sang | - |
dc.contributor.author | Yoo, Soon Jib | - |
dc.date.accessioned | 2023-12-01T07:40:09Z | - |
dc.date.available | 2023-12-01T07:40:09Z | - |
dc.date.created | 2023-12-01 | - |
dc.date.issued | 2023-08 | - |
dc.identifier.issn | 2093-596X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/44661 | - |
dc.description.abstract | Background: The effects of dipeptidyl peptidase 4 (DPP-4) inhibitors over the course of long-term treatment remain unclear, and concerns have been raised regarding the role of DPP-4 inhibitors in carcinogenesis in the pancreas. Earlier studies of pancreatic adverse events have reported conflicting results.Methods: This study analyzed Korean National Health Insurance Service data from January 2009 to December 2012. Patients who had type 2 diabetes mellitus and took two or more oral glucose-lowering drugs (GLDs) were included. Patients prescribed DPP-4 inhibitors (n=51,482) or other GLDs (n=51,482) were matched at a 1:1 ratio using propensity score matching. The risk of pancreatic cancer was calculated using Kaplan-Meier curves and Cox proportional-hazards regression analysis.Results: During a median follow-up period of 7.95 years, 1,051 new cases of pancreatic cancer were identified. The adjusted hazard ratio (HR) for DPP-4 inhibitor use was 0.99 (95% confidence interval [CI], 0.88 to 1.12) compared with the other GLD group. In an analysis limited to cases diagnosed with pancreatic cancer during hospitalization, the adjusted HR for the use of DPP-4 inhibitors was 1.00 (95% CI, 0.86 to 1.17) compared with patients who took other GLDs. Using the other GLD group as the reference group, no trend was observed for elevated pancreatic cancer risk with increased DPP-4 inhibitor exposure.Conclusion: In this population-based cohort study, DPP-4 inhibitor use over the course of relatively long-term follow-up showed no significant association with an elevated risk of pancreatic cancer. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ENDOCRINE SOC | - |
dc.relation.isPartOf | ENDOCRINOLOGY AND METABOLISM | - |
dc.title | Risk of Pancreatic Cancer and Use of Dipeptidyl Peptidase 4 Inhibitors in Patients with Type 2 Diabetes: A Propensity Score-Matching Analysis | - |
dc.type | Article | - |
dc.identifier.doi | 10.3803/EnM.2023.1737 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | ENDOCRINOLOGY AND METABOLISM, v.38, no.4, pp.426 - 435 | - |
dc.identifier.kciid | ART002991339 | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 001085474800008 | - |
dc.identifier.scopusid | 2-s2.0-85169671129 | - |
dc.citation.endPage | 435 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 426 | - |
dc.citation.title | ENDOCRINOLOGY AND METABOLISM | - |
dc.citation.volume | 38 | - |
dc.contributor.affiliatedAuthor | Han, Kyungdo | - |
dc.identifier.url | https://www.e-enm.org/journal/view.php?doi=10.3803/EnM.2023.1737 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordAuthor | Pancreatic carcinoma | - |
dc.subject.keywordAuthor | Dipeptidyl-peptidase IV inhibitors | - |
dc.subject.keywordAuthor | Diabetes mellitus | - |
dc.subject.keywordAuthor | type 2 | - |
dc.subject.keywordPlus | TRENDS | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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