Risk of Cause-Specific Mortality across Glucose Spectrum in Elderly People: A Nationwide Population-Based Cohort Study
DC Field | Value | Language |
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dc.contributor.author | Lee, Joonyub | - |
dc.contributor.author | Kim, Hun-Sung | - |
dc.contributor.author | Song, Kee-Ho | - |
dc.contributor.author | Yoo, Soon Jib | - |
dc.contributor.author | Han, Kyungdo | - |
dc.contributor.author | Lee, Seung-Hwan | - |
dc.date.accessioned | 2024-02-02T07:30:20Z | - |
dc.date.available | 2024-02-02T07:30:20Z | - |
dc.date.issued | 2023-10 | - |
dc.identifier.issn | 2093-596X | - |
dc.identifier.issn | 2093-5978 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/49121 | - |
dc.description.abstract | Background: This study investigated the risk of cause-specific mortality according to glucose tolerance status in elderly South Koreans.Methods: A total of 1,292,264 individuals aged >= 65 years who received health examinations in 2009 were identified from the Na-tional Health Information Database. Participants were classified as normal glucose tolerance, impaired fasting glucose, newly-diag-nosed diabetes, early diabetes (oral hypoglycemic agents <= 2), or advanced diabetes (oral hypoglycemic agents >= 3 or insulin). The risk of system-specific and disease-specific deaths was estimated using multivariate Cox proportional hazards analysis.Results: During a median follow-up of 8.41 years, 257,356 deaths were recorded. Diabetes was associated with significantly higher risk of all-cause mortality (hazard ratio [HR], 1.58; 95% confidence interval [CI], 1.57 to 1.60); death due to circulatory (HR, 1.49; 95% CI, 1.46 to 1.52), respiratory (HR, 1.51; 95% CI, 1.47 to 1.55), and genitourinary systems (HR, 2.22; 95% CI, 2.10 to 2.35); and neoplasms (HR, 1.30; 95% CI, 1.28 to 1.32). Diabetes was also associated with a significantly higher risk of death due to ischemic heart disease (HR, 1.70; 95% CI, 1.63 to 1.76), cerebrovascular disease (HR, 1.46; 95% CI, 1.41 to 1.50), pneumonia (HR, 1.69; 95% CI, 1.63 to 1.76), and acute or chronic kidney disease (HR, 2.23; 95% CI, 2.09 to 2.38). There was a stepwise increase in the risk of death across the glucose spectrum (P for trend <0.0001). Stroke, heart failure, or chronic kidney disease increased the risk of all-cause mortality at every stage of glucose intolerance.Conclusion: A dose-dependent association between the risk of mortality from various causes and severity of glucose tolerance was noted in the elderly population. | - |
dc.format.extent | 13 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN ENDOCRINE SOC | - |
dc.title | Risk of Cause-Specific Mortality across Glucose Spectrum in Elderly People: A Nationwide Population-Based Cohort Study | - |
dc.type | Article | - |
dc.identifier.doi | 10.3803/EnM.2023.1765 | - |
dc.identifier.bibliographicCitation | ENDOCRINOLOGY AND METABOLISM, v.38, no.5, pp 525 - 537 | - |
dc.identifier.kciid | ART003010626 | - |
dc.identifier.wosid | 001108650400002 | - |
dc.identifier.scopusid | 2-s2.0-85176305806 | - |
dc.citation.endPage | 537 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 525 | - |
dc.citation.title | ENDOCRINOLOGY AND METABOLISM | - |
dc.citation.volume | 38 | - |
dc.identifier.url | https://www.e-enm.org/journal/view.php?doi=10.3803/EnM.2023.1765 | - |
dc.publisher.location | 대한민국 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordAuthor | Diabetes mellitus | - |
dc.subject.keywordAuthor | Aged | - |
dc.subject.keywordAuthor | Glucose tolerance | - |
dc.subject.keywordAuthor | Mortality | - |
dc.subject.keywordPlus | ALL-CAUSE | - |
dc.subject.keywordPlus | TYPE-2 | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | TRENDS | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | SCORE | - |
dc.subject.keywordPlus | AGE | - |
dc.subject.keywordPlus | VALIDATION | - |
dc.subject.keywordPlus | PREDICTION | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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