Crystal Structure of Glycerol Dehydrogenase from Klebsiella pneumoniae
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ko, Gyeong Soo | - |
dc.contributor.author | Nguyen, Thang Quyet | - |
dc.contributor.author | Koh, Seri | - |
dc.contributor.author | Kang, Wonchull | - |
dc.date.accessioned | 2024-03-12T05:30:20Z | - |
dc.date.available | 2024-03-12T05:30:20Z | - |
dc.date.issued | 2024-02 | - |
dc.identifier.issn | 1017-2548 | - |
dc.identifier.issn | 2234-8530 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/49264 | - |
dc.description.abstract | Glycerol dehydrogenase (GlyDH) plays a crucial role in the glycerol metabolism pathway by catalyzing the oxidation of glycerol to dihydroxyacetone (DHA). Previous studies of GlyDH have predominantly focused on unraveling the structural features of the active site and its binding interactions with ligand. However, the structural details of GlyDH in complex with both NAD+ and the substrate bound have remained elusive. In this study, we present the crystal structures of Klebsiella pneumoniae GlyDH (KpGlyDH) in the absence and presence of NAD+ at a resolution of 2.1 Å. Notably, both structures reveal the binding of the substrate, ethylene glycol, to the zinc ion. Interestingly, a significant change in the coordination number of the zinc ion is observed, with three in the absence of NAD+ and four in its presence. These findings shed light on the structural aspects of GlyDH and its interactions with NAD+ and the substrate. © 2024 Korean Chemical Society. All rights reserved. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Korean Chemical Society | - |
dc.title | Crystal Structure of Glycerol Dehydrogenase from Klebsiella pneumoniae | - |
dc.type | Article | - |
dc.identifier.doi | 10.5012/jkcs.2024.68.1.32 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Chemical Society, v.68, no.1, pp 32 - 39 | - |
dc.identifier.kciid | ART003050870 | - |
dc.identifier.wosid | 001168245800006 | - |
dc.identifier.scopusid | 2-s2.0-85185538102 | - |
dc.citation.endPage | 39 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 32 | - |
dc.citation.title | Journal of the Korean Chemical Society | - |
dc.citation.volume | 68 | - |
dc.publisher.location | 대한민국 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordAuthor | Biofuel | - |
dc.subject.keywordAuthor | Ethylene glycol | - |
dc.subject.keywordAuthor | GldA | - |
dc.subject.keywordAuthor | Glycerol | - |
dc.subject.keywordAuthor | Glycerol dehydrogenase | - |
dc.subject.keywordPlus | ESCHERICHIA-COLI | - |
dc.subject.keywordPlus | MOLECULAR CHARACTERIZATION | - |
dc.subject.keywordPlus | PURIFICATION | - |
dc.subject.keywordPlus | 1,3-PROPANEDIOL | - |
dc.subject.keywordPlus | REGENERATION | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | esci | - |
dc.description.journalRegisteredClass | kci | - |
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