Combination of early rhythm control and healthy lifestyle on the risk of stroke in elderly patients with new-onset atrial fibrillation: a nationwide population-based cohort study
DC Field | Value | Language |
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dc.contributor.author | Lim, Woo-Hyun | - |
dc.contributor.author | Lee, So-Ryoung | - |
dc.contributor.author | Choi, Eue-Keun | - |
dc.contributor.author | Lee, Seung-Woo | - |
dc.contributor.author | Han, Kyung-Do | - |
dc.contributor.author | Oh, Seil | - |
dc.contributor.author | Lip, Gregory Y. H. | - |
dc.date.accessioned | 2024-04-04T02:30:20Z | - |
dc.date.available | 2024-04-04T02:30:20Z | - |
dc.date.issued | 2024-02 | - |
dc.identifier.issn | 2297-055X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/49340 | - |
dc.description.abstract | Background: The impact of early rhythm control (ERC) combined with healthy lifestyle (HLS) on the risk of ischemic stroke in elderly patients with atrial fibrillation (AF) remains unaddressed. Objective: To evaluate the impact of combined ERC and HLS on the risk of stroke in elderly patients with new-onset AF. Methods: Using the Korean National Health Insurance Service database, we included patients aged >= 75 years with new-onset AF from January 2009 to December 2016 (n = 41,315). Patients who received rhythm control therapy within 2 years of AF diagnosis were defined as the ERC group. Non-smoking, non-to-mild alcohol consumption (<105 g/week), and regular exercise were defined as HLS. Subjects were categorized into four groups: group 1 (without ERC and HLS, n = 25,093), 2 (HLS alone, n = 8,351), 3 (ERC alone, n = 5,565), and 4 (both ERC and HLS, n = 2,306). We assessed the incidence of ischemic stroke as the primary outcome, along with admissions for heart failure, all-cause death, and the composite of ischemic stroke, admission for heart failure, and all-cause death. Results: Median follow-up duration of the study cohort was 3.4 years. After adjusting for multiple variables, groups 2 and 3 were associated with a lower stroke risk (adjusted hazard ratio [aHR]: 95% confidence interval [CI]: 0.867, 0.794-0.948 and 0.713, 0.637-0.798, respectively) than that of group 1. Compared to Group 1, group 4 showed the lowest stroke risk (aHR: 0.694, 95% CI: 0.586-0.822) among all groups, followed by group 3 (0.713, 0.637-0.798) and group 2 (0.857, 0.794-0.948), respectively. Group 4 was associated with the lowest risk of all-cause death (aHR: 0.680, 95% CI: 0.613-0.754) and the composite outcome (aHR: 0.708, 95% CI: 0.649-0.772). Conclusion: ERC and HLS were associated with a lower risk of ischemic stroke in elderly patients with new-onset AF. Concurrently implementing ERC and maintaining HLS was associated with the lowest risk of death and the composite outcome, with a modest synergistic effect on stroke prevention. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.title | Combination of early rhythm control and healthy lifestyle on the risk of stroke in elderly patients with new-onset atrial fibrillation: a nationwide population-based cohort study | - |
dc.type | Article | - |
dc.identifier.doi | 10.3389/fcvm.2024.1346414 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN CARDIOVASCULAR MEDICINE, v.11 | - |
dc.identifier.wosid | 001175060300001 | - |
dc.identifier.scopusid | 2-s2.0-85186234967 | - |
dc.citation.title | FRONTIERS IN CARDIOVASCULAR MEDICINE | - |
dc.citation.volume | 11 | - |
dc.identifier.url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1346414/full | - |
dc.publisher.location | 스위스 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordAuthor | atrial fibrillation | - |
dc.subject.keywordAuthor | rhythm control | - |
dc.subject.keywordAuthor | lifestyle modification | - |
dc.subject.keywordAuthor | stroke | - |
dc.subject.keywordAuthor | elderly | - |
dc.subject.keywordPlus | ALCOHOL ABSTINENCE | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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