Impact of Antidiabetic Drugs on Clinical Outcomes of COVID-19: A Nationwide Population-Based Study
DC Field | Value | Language |
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dc.contributor.author | 장한나 | - |
dc.contributor.author | 문선준 | - |
dc.contributor.author | 정진형 | - |
dc.contributor.author | 한경도 | - |
dc.contributor.author | 이은정 | - |
dc.contributor.author | 이원영 | - |
dc.date.accessioned | 2024-08-01T02:30:25Z | - |
dc.date.available | 2024-08-01T02:30:25Z | - |
dc.date.issued | 2024-06 | - |
dc.identifier.issn | 2093-596X | - |
dc.identifier.issn | 2093-5978 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/49895 | - |
dc.description.abstract | Background: Inconsistent results have been reported regarding the association between the use of antidiabetic drugs and the clinical outcomes of coronavirus disease 2019 (COVID-19). This study aimed to investigate the effect of antidiabetic drugs on COVID-19 outcomes in patients with diabetes using data from the National Health Insurance Service (NHIS) in South Korea. Methods: We analyzed the NHIS data of patients aged ≥20 years who tested positive for COVID-19 and were taking antidiabetic drugs between December 2019 and June 2020. Multiple logistic regression analysis was performed to analyze the clinical outcomes of COVID-19 based on the use of antidiabetic drugs. Results: A total of 556 patients taking antidiabetic drugs tested positive for COVID-19, including 271 male (48.7%), most of whom were in their sixties. Of all patients, 433 (77.9%) were hospitalized, 119 (21.4%) received oxygen treatment, 87 (15.6%) were admitted to the intensive care unit, 31 (5.6%) required mechanical ventilation, and 61 (11.0%) died. Metformin was significantly associated with the lower risks of mechanical ventilation (odds ratio [OR], 0.281; 95% confidence interval [CI], 0.109 to 0.720; P=0.008), and death (OR, 0.395; 95% CI, 0.182 to 0.854; P=0.018). Dipeptidylpeptidase-4 inhibitor (DPP-4i) were significantly associated with the lower risks of oxygen treatment (OR, 0.565; 95% CI, 0.356 to 0.895; P=0.015) and death (OR, 0.454; 95% CI, 0.217 to 0.949; P=0.036). Sulfonylurea was significantly associated with the higher risk of mechanical ventilation (OR, 2.579; 95% CI, 1.004 to 6.626; P=0.049). Conclusion: In patients with diabetes and COVID-19, metformin exhibited reduced risks of mechanical ventilation and death, DPP-4i was linked with lower risks of oxygen treatment and death, while sulfonylurea was related to the increased risk of mechanical ventilation. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한내분비학회 | - |
dc.title | Impact of Antidiabetic Drugs on Clinical Outcomes of COVID-19: A Nationwide Population-Based Study | - |
dc.title.alternative | Impact of Antidiabetic Drugs on Clinical Outcomes of COVID-19: A Nationwide Population-Based Study | - |
dc.type | Article | - |
dc.identifier.doi | 10.3803/EnM.2023.1857 | - |
dc.identifier.bibliographicCitation | Endocrinology and Metabolism, v.39, no.3, pp 479 - 488 | - |
dc.identifier.kciid | ART003090985 | - |
dc.identifier.wosid | 001255371700010 | - |
dc.identifier.scopusid | 2-s2.0-85198518343 | - |
dc.citation.endPage | 488 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 479 | - |
dc.citation.title | Endocrinology and Metabolism | - |
dc.citation.volume | 39 | - |
dc.identifier.url | https://www.e-enm.org/journal/view.php?doi=10.3803/EnM.2023.1857 | - |
dc.publisher.location | 대한민국 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordAuthor | SARS-CoV-2 | - |
dc.subject.keywordAuthor | COVID-19 | - |
dc.subject.keywordAuthor | Clinical outcome | - |
dc.subject.keywordAuthor | Metformin | - |
dc.subject.keywordAuthor | Dipeptidylpeptidase-4 inhibitor | - |
dc.subject.keywordAuthor | Sulfonylurea | - |
dc.subject.keywordPlus | CORONAVIRUS DISEASE 2019 | - |
dc.subject.keywordPlus | METFORMIN | - |
dc.subject.keywordPlus | INSULIN | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | SEVERITY | - |
dc.subject.keywordPlus | ACIDOSIS | - |
dc.subject.keywordPlus | AGENTS | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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