Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이채영 | - |
dc.date.available | 2018-05-07T11:11:59Z | - |
dc.date.created | 2018-04-18 | - |
dc.date.issued | 2016-01 | - |
dc.identifier.issn | 0028-3878 | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/5583 | - |
dc.description.abstract | Objective:For 3,670 stroke patients from the United Kingdom, United States, Australia, Belgium, and Italy, we performed a genome-wide meta-analysis of white matter hyperintensity volumes (WMHV) on data imputed to the 1000 Genomes reference dataset to provide insights into disease mechanisms.Methods:We first sought to identify genetic associations with white matter hyperintensities in a stroke population, and then examined whether genetic loci previously linked to WMHV in community populations are also associated in stroke patients. Having established that genetic associations are shared between the 2 populations, we performed a meta-analysis testing which associations with WMHV in stroke-free populations are associated overall when combined with stroke populations.Results:There were no associations at genome-wide significance with WMHV in stroke patients. All previously reported genome-wide significant associations with WMHV in community populations shared direction of effect in stroke patients. In a meta-analysis of the genome-wide significant and suggestive loci (p < 5 x 10(-6)) from community populations (15 single nucleotide polymorphisms in total) and from stroke patients, 6 independent loci were associated with WMHV in both populations. Four of these are novel associations at the genome-wide level (rs72934505 [NBEAL1], p = 2.2 x 10(-8); rs941898 [EVL], p = 4.0 x 10(-8); rs962888 [C1QL1], p = 1.1 x 10(-8); rs9515201 [COL4A2], p = 6.9 x 10(-9)).Conclusions:Genetic associations with WMHV are shared in otherwise healthy individuals and patients with stroke, indicating common genetic susceptibility in cerebral small vessel disease. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS WILKINS | - |
dc.relation.isPartOf | NEUROLOGY | - |
dc.title | Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke | - |
dc.type | Article | - |
dc.identifier.doi | 10.1212/WNL.0000000000002263 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | NEUROLOGY, v.86, no.2, pp.146 - 153 | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000368454800008 | - |
dc.identifier.scopusid | 2-s2.0-84954318325 | - |
dc.citation.endPage | 153 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 146 | - |
dc.citation.title | NEUROLOGY | - |
dc.citation.volume | 86 | - |
dc.contributor.affiliatedAuthor | 이채영 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
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