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A metabolomics strategy for detecting protein-metabolite interactions to identify natural nuclear receptor ligands
- Authors
- Kim, Yun-Gon; Lou, Angela C.; Saghatelian, Alan
- Issue Date
- Mar-2011
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- MOLECULAR BIOSYSTEMS, v.7, no.4, pp.1046 - 1049
- Journal Title
- MOLECULAR BIOSYSTEMS
- Volume
- 7
- Number
- 4
- Start Page
- 1046
- End Page
- 1049
- ISSN
- 1742-206X
- Abstract
- Nuclear receptors are ligand-regulated transcription factors that control a range of (patho) physiological processes. Lipids are the most common type of nuclear receptor ligands. Here, we utilize a metabolomics approach that detects protein-metabolite interactions to identify endogenous peroxisome proliferator-activated receptor (PPAR) ligands from tissue and cell extracts.
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Related Researcher
- Kim, Yun Gon
- College of Engineering (Department of Chemical)