Molecular evolution of the periphilin gene in relation to human endogenous retrovirus M element
- Authors
- Huh, JW; Kim, TH; Yi, JM; Park, ES; Kim, WY; Sin, HS; Kim, DS; Min, DS; Kim, SS; Kim, CB; Hyun, BH; Kang, SK; Jung, JS; Lee, WH; Takenaka, O; Kim, HS
- Issue Date
- Jun-2006
- Publisher
- SPRINGER
- Citation
- JOURNAL OF MOLECULAR EVOLUTION, v.62, pp.730 - 737
- Journal Title
- JOURNAL OF MOLECULAR EVOLUTION
- Volume
- 62
- Start Page
- 730
- End Page
- 737
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/6141
- DOI
- 10.1007/s00239-005-0109-0
- ISSN
- 0022-2844
- Abstract
- HERV-M (human endogenous retrovirus M), related to the super family of HERV-K, has a methionine (M) tRNA primer-binding site, and is located within the periphilin gene on human chromosome 12q12. HERV-M has been integrated into the periphilin gene as the truncated form, 5'LTR-gag-pol-3'LTR. Polymerase chain reaction (PCR) and reverse transcription-polymerase chain reaction (RT-PCR) approaches were conducted to investigate its evolutionary origins. Interestingly, the insertion of retroelements in a common ancestor genome can make different transcript variants in different species. In the case of the periphilin gene, human (10 variants) and mouse (2 variants) lineages show different transcript variants. Insertion of HERV-M (variant 1-3) could affect the protein-coding region. Also, Alusq/x (variant 4-9) and L1ME4a (mammalian-wide subfamilies of LINE-1) (variant 10) in humans and SINE (short interspersed repetitive element) and RLTR15 (the mouse putative long terminal repeat) (variant 2) in mice could be driving forces in transcript diversification of the periphilin gene during mammalian evolution. The HERV-M derived transcripts (variant 1-3) were expressed in different human tissues, whereas they were not detected in crab-eating monkey and squirrel monkey tissues by RT-PCR amplification. Taken together, HERV-M seems to have been integrated into our common ancestor genome after the divergence of simians and prosimians, and then was actively expressed during hominoid evolution.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Natural Sciences > School of Systems and Biomedical Science > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/6141)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.