The carboxy-terminal region of the TBC1D4 (AS160) RabGAP mediates protein homodimerization
DC Field | Value | Language |
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dc.contributor.author | Woo, Ju Rang | - |
dc.contributor.author | Kim, Soon-Jong | - |
dc.contributor.author | Kim, Keon Young | - |
dc.contributor.author | Jang, Hyonchol | - |
dc.contributor.author | Shoelson, Steven E. | - |
dc.contributor.author | Park, SangYoun | - |
dc.date.available | 2018-05-08T14:28:46Z | - |
dc.date.created | 2018-04-17 | - |
dc.date.issued | 2017-10 | - |
dc.identifier.issn | 0141-8130 | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/6224 | - |
dc.description.abstract | TBC1D4 (also known as AS160) is a Rab GTPase-activating protein (RabGAP) which functions in insulin signaling. TBC1D4 is critical for translocation of glucose transporter 4 (GLUT4), from an inactive, intra-cellular, vesicle-bound site to the plasma membrane, where it promotes glucose entry into cells. The TBC1D4 protein is structurally subdivided into two N-terminal phosphotyrosine-binding (PTB) domains, a C-terminal catalytic RabGAP domain, and a disordered segment in between containing potential Akt phosphorylation sites. Structural predictions further suggest that a region C-terminal to the RabGAP domain adopts a coiled-coil motif. We show that C-terminal region (CTR) region is largely a-helical and mediates TBC1D4 RabGAP dimerization. RabGAP catalytic activity and thermal stability appear to be independent of CTR-mediated dimerization. (C) 2017 Elsevier B.V. All rights reserved. | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | - |
dc.subject | INSULIN-REGULATED AMINOPEPTIDASE | - |
dc.subject | PHOSPHOTYROSINE-BINDING DOMAIN | - |
dc.subject | GLUT4 TRANSLOCATION | - |
dc.subject | PLASMA-MEMBRANE | - |
dc.subject | AKT SUBSTRATE | - |
dc.subject | GAP | - |
dc.subject | GLUCOSE-TRANSPORTER-4 | - |
dc.subject | RAB10 | - |
dc.title | The carboxy-terminal region of the TBC1D4 (AS160) RabGAP mediates protein homodimerization | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.ijbiomac.2017.05.119 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, v.103, pp.965 - 971 | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000408286400110 | - |
dc.identifier.scopusid | 2-s2.0-85020030327 | - |
dc.citation.endPage | 971 | - |
dc.citation.startPage | 965 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | - |
dc.citation.volume | 103 | - |
dc.contributor.affiliatedAuthor | Park, SangYoun | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | TBC1D4 | - |
dc.subject.keywordAuthor | AS160 | - |
dc.subject.keywordAuthor | TBC1D1 | - |
dc.subject.keywordAuthor | Dimerization | - |
dc.subject.keywordAuthor | Coiled-coil | - |
dc.subject.keywordAuthor | RabGAP | - |
dc.subject.keywordPlus | INSULIN-REGULATED AMINOPEPTIDASE | - |
dc.subject.keywordPlus | PHOSPHOTYROSINE-BINDING DOMAIN | - |
dc.subject.keywordPlus | GLUT4 TRANSLOCATION | - |
dc.subject.keywordPlus | PLASMA-MEMBRANE | - |
dc.subject.keywordPlus | AKT SUBSTRATE | - |
dc.subject.keywordPlus | GAP | - |
dc.subject.keywordPlus | GLUCOSE-TRANSPORTER-4 | - |
dc.subject.keywordPlus | RAB10 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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