JS-III-49, a hydroquinone derivative, exerts anti-inflammatory activity by targeting Akt and p38
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yi, Young-Su | - |
dc.contributor.author | Kim, Mi-Yeon | - |
dc.contributor.author | Cho, Jae Youl | - |
dc.date.available | 2018-05-08T14:43:19Z | - |
dc.date.created | 2018-04-17 | - |
dc.date.issued | 2017-05 | - |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/6385 | - |
dc.description.abstract | Since previous studies have reported that hydroquinone (HQ) exerted immunosuppressive and anti-inflammatory activity, various HQ derivatives have been synthesized and their biological activities investigated. In this study, we explored the anti-inflammatory activity of JS-III-49, a novel HQ derivative, in macrophage mediated inflammatory responses. JS-III-49 suppressed the production of the inflammatory mediators nitric oxide (NO) and prostaglandin E-2, (PGE(2)) and down regulated the mRNA expression of the inflammatory enzymes cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) as well as the expression of the pro-inflammatory cytokines interleukin-6 (IL-6) and IL-1 beta without cytotoxicity in LPS-stimulated RAW264.7 cells. JS-III-49 inhibited nuclear translocation of the NF-kappa B transcription factors p65 and p50 by directly targeting Akt, an upstream kinase of the NF-kappa B pathway, in LPS-stimulated RAW264.7 cells. However, JS-III-49 did not directly inhibit the kinase activities of Src and Syk, which are upstream kinases of Akt, in LPS-stimulated RAW264.7 cells. Moreover, JS-III-49 suppressed the nuclear translocation of c-Fos, one of the components of AP-1, by specifically targeting p38, an upstream mitogen-activated protein kinase (MAPK) in the AP-1 pathway in LPS-stimulated RAW264.7 cells. These results suggest that JS-III-49 plays an anti-inflammatory role in LPS-stimulated macrophages by targeting Akt and p38 in the NF-kappa B and AP-1 pathways, respectively. | - |
dc.publisher | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.relation.isPartOf | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.subject | FACTOR-KAPPA-B | - |
dc.subject | INFLAMMATORY RESPONSES | - |
dc.subject | REACTIVE METABOLITE | - |
dc.subject | IN-VITRO | - |
dc.subject | ETHANOL EXTRACT | - |
dc.subject | INHIBITION | - |
dc.subject | SRC | - |
dc.subject | ACTIVATION | - |
dc.subject | BENZENE | - |
dc.subject | KINASE | - |
dc.title | JS-III-49, a hydroquinone derivative, exerts anti-inflammatory activity by targeting Akt and p38 | - |
dc.type | Article | - |
dc.identifier.doi | 10.4196/kjpp.2017.21.3.345 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v.21, no.3, pp.345 - 352 | - |
dc.identifier.kciid | ART002217152 | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000401214800009 | - |
dc.identifier.scopusid | 2-s2.0-85019708261 | - |
dc.citation.endPage | 352 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 345 | - |
dc.citation.title | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.citation.volume | 21 | - |
dc.contributor.affiliatedAuthor | Kim, Mi-Yeon | - |
dc.type.docType | Article | - |
dc.description.oadoiVersion | published | - |
dc.subject.keywordAuthor | Akt | - |
dc.subject.keywordAuthor | Anti-inflammatory activity | - |
dc.subject.keywordAuthor | HQ derivative | - |
dc.subject.keywordAuthor | JS-III-49 | - |
dc.subject.keywordAuthor | Macrophages | - |
dc.subject.keywordAuthor | p38 | - |
dc.subject.keywordPlus | FACTOR-KAPPA-B | - |
dc.subject.keywordPlus | INFLAMMATORY RESPONSES | - |
dc.subject.keywordPlus | REACTIVE METABOLITE | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | ETHANOL EXTRACT | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | SRC | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | BENZENE | - |
dc.subject.keywordPlus | KINASE | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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