Hierarchically Micro- and Nanopatterned Topographical Cues for Modulation of Cellular Structure and Function
DC Field | Value | Language |
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dc.contributor.author | Seonwoo, Hoon | - |
dc.contributor.author | Bae, Won-Gyu | - |
dc.contributor.author | Park, Sunho | - |
dc.contributor.author | Kim, Hong-Nam | - |
dc.contributor.author | Choi, Kyoung Soon | - |
dc.contributor.author | Lim, Ki Taek | - |
dc.contributor.author | Hyun, Hoon | - |
dc.contributor.author | Kim, Jin-Woo | - |
dc.contributor.author | Kim, Jangho | - |
dc.contributor.author | Chung, Jong Hoon | - |
dc.date.available | 2018-05-09T02:10:38Z | - |
dc.date.created | 2018-04-17 | - |
dc.date.issued | 2016-12 | - |
dc.identifier.issn | 1536-1241 | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/7444 | - |
dc.description.abstract | Living cells receive biochemical and physical information from the surrounding microenvironment and respond to this information. Multiscale hierarchical substrates with micro-and nanogrooves have been shown to mimic the native extracellular matrix (ECM) better than conventional nanopatterned substrates; therefore, substrates with hierarchical topographical cues are considered suitable for investigating the role of physical factors in tissue functions. In this study, precisely controllable, multiscale hierarchical substrates that could mimic the micro-and nanotopography of complex ECMs were fabricated and used to culture various cell types, including fibroblasts, endothelial cells, osteoblasts, and human mesenchymal stem cells. These substrates had both microscale wrinkles and nanoscale patterns and enhanced the alignment and elongation of all the cells tested. In particular, the nanotopography on the microscale wrinkles promoted not only the adhesion, but also the functions of the cells. These findings suggest that the hierarchical multiscale substrates effectively regulated cellular structure and functions and that they can be used as a platform for tissue engineering and regenerative medicine. | - |
dc.publisher | IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC | - |
dc.relation.isPartOf | IEEE TRANSACTIONS ON NANOBIOSCIENCE | - |
dc.subject | MESENCHYMAL STEM-CELLS | - |
dc.subject | EXTRACELLULAR-MATRIX | - |
dc.subject | ELASTOMERIC POLYMER | - |
dc.subject | NANOTOPOGRAPHY | - |
dc.subject | CONSTRUCTS | - |
dc.subject | WOUNDS | - |
dc.subject | FATE | - |
dc.title | Hierarchically Micro- and Nanopatterned Topographical Cues for Modulation of Cellular Structure and Function | - |
dc.type | Article | - |
dc.identifier.doi | 10.1109/TNB.2016.2631641 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | IEEE TRANSACTIONS ON NANOBIOSCIENCE, v.15, no.8, pp.835 - 842 | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000394111400007 | - |
dc.identifier.scopusid | 2-s2.0-85010403569 | - |
dc.citation.endPage | 842 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 835 | - |
dc.citation.title | IEEE TRANSACTIONS ON NANOBIOSCIENCE | - |
dc.citation.volume | 15 | - |
dc.contributor.affiliatedAuthor | Bae, Won-Gyu | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | alignment | - |
dc.subject.keywordAuthor | cell elongation | - |
dc.subject.keywordAuthor | fibroblasts | - |
dc.subject.keywordAuthor | hierarchical structure | - |
dc.subject.keywordAuthor | mesenchymal stem cells | - |
dc.subject.keywordPlus | MESENCHYMAL STEM-CELLS | - |
dc.subject.keywordPlus | EXTRACELLULAR-MATRIX | - |
dc.subject.keywordPlus | ELASTOMERIC POLYMER | - |
dc.subject.keywordPlus | NANOTOPOGRAPHY | - |
dc.subject.keywordPlus | CONSTRUCTS | - |
dc.subject.keywordPlus | WOUNDS | - |
dc.subject.keywordPlus | FATE | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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