Paper Strip-based Fluorometric Determination of Cyanide with an Internal Reference
- Authors
- Lee, Dong-Nam; Seo, Hyejin; Shin, Ik-Soo; Hong, Jong-In
- Issue Date
- Aug-2016
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- Cyanide; Fluorescent probe; Paper strip; Point-of-care testing; Internal reference
- Citation
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.37, no.8, pp.1320 - 1325
- Journal Title
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY
- Volume
- 37
- Number
- 8
- Start Page
- 1320
- End Page
- 1325
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/7544
- DOI
- 10.1002/bkcs.10863
- ISSN
- 0253-2964
- Abstract
- The rapid, selective, and sensitive determination of cyanide anion (CN (-)) using a simple paper strip is highly attractive because cyanide is acutely lethal to living organisms via all routes of administration, including alcohol consumption and inhaling cigarette smoke. Here, a synthetic probe (1) was designed for the selective determination of cyanide. The probe displays rapid and large blue spectral change ((abs) =148 nm, (em) = 165 nm) with respect to target recognition. Probe 1 exhibits a strong push-pull electronic effect and comprises a dimethylaminoaryl group as a donor and malononitrile as an acceptor; the -conjugation system can be destroyed by the Michael-type addition of cyanide at the electrophilic -positions of the nitrile groups, resulting in the marked emergence of a peak at (em) = 515 nm. The developed probe was successfully applied to a paper test strip because of its noticeable optical changes upon reaction with cyanide. The fabricated dumbbell-shaped paper strip with an internal reference allowed the cyanide detection, which is indispensable for quantitative analysis in point-of-care testing. The paper strip test showed selective response to cyanide, with a linear correlation in the range of 0-25 mM in a simple and cost-effective manner.
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Collections - College of Natural Sciences > Department of Chemistry > 1. Journal Articles
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