Genome-wide association study reveals sex-specific selection signals against autosomal nucleotide variants
- Authors
- Ryu, Dongchan; Ryu, Jihye; Lee, Chaeyoung
- Issue Date
- May-2016
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- JOURNAL OF HUMAN GENETICS, v.61, no.5, pp.423 - 426
- Journal Title
- JOURNAL OF HUMAN GENETICS
- Volume
- 61
- Number
- 5
- Start Page
- 423
- End Page
- 426
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/7620
- DOI
- 10.1038/jhg.2015.169
- ISSN
- 1434-5161
- Abstract
- A genome-wide association study (GWAS) was conducted to examine genetic associations of common autosomal nucleotide variants with sex in a Korean population with 4183 males and 4659 females. Nine genetic association signals were identified in four intragenic and five intergenic regions (P<5 x 10(-8)). Further analysis with an independent data set confirmed two intragenic association signals in the genes encoding protein phosphatase 1, regulatory subunit 12B (PPP1R12B, intron 12, rs1819043) and dynein, axonemal, heavy chain 11 (DNAH11, intron 61, rs10255013), which are directly involved in the reproductive system. This study revealed autosomal genetic variants associated with sex ratio by GWAS for the first time. This implies that genetic variants in proximity to the association signals may influence sex-specific selection and contribute to sex ratio variation. Further studies are required to reveal the mechanisms underlying sex-specific selection.
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Collections - College of Natural Sciences > School of Systems and Biomedical Science > 1. Journal Articles
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