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PEGylation density-modulated anticancer drug release on gold nanoparticles in live cells
- Issue Date
- 23-Jan-2016
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- PEGylation density; Intracellular anticancer drug release modulation; Gold nanoparticles; Live cells; Bimodal spectroscopic imaging
- Citation
- JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.33, pp.345 - 354
- Journal Title
- JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
- Volume
- 33
- Start Page
- 345
- End Page
- 354
- ISSN
- 1226-086X
- Abstract
- Glutathione (GSH)-triggered drug releases of the anticancer drug mitoxantrone from a polyethylene glycol (PEG) (molecular weight: 5000) density-modulated drug delivery system up to 0.57 nm(-2) of gold nanoparticles (AuNPs) were examined using bimodal spectroscopic imaging techniques of live-cell fluorescence imaging and surface-enhanced resonance Raman scattering (SERRS). Prolonged delivery amounts and sustained drug releases after introducing a high PEG density on AuNPs was supported by a cell viability test in HeLa cells. A subcutaneous in vivo test also indicated that the SERRS spectra could be observed only for the PEGylated AuNPs after external GSH treatment in consistent with the fluorescence measurements. (C) 2015 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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Related Researcher
- Joo, Sang Woo
- College of Natural Sciences (Department of Chemistry)