Poly(acrylic acid) to induce competitive crystallization of a theophylline/oxalic acid cocrystal and a theophylline polymorph
- Authors
- Jang, Jisun; Kim, Il Won
- Issue Date
- Jan-2016
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Crystal structure; Crystal morphology; Growth from solutions; Organic compounds Polymers
- Citation
- JOURNAL OF CRYSTAL GROWTH, v.434, pp.104 - 109
- Journal Title
- JOURNAL OF CRYSTAL GROWTH
- Volume
- 434
- Start Page
- 104
- End Page
- 109
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/7714
- DOI
- 10.1016/j.jcrysgro.2015.11.004
- ISSN
- 0022-0248
- Abstract
- Polymeric additives to induce competitive crystallization of pharmaceutical compounds were explored. A cocrystal of theophylline and oxalic acid was used as a model system, and poly(acrylic acid), poly (caprolactone), and poly(ethylene glycol) were the additives. The cocrystal formation was selectively hindered with addition of poly(acrylic acid). First the size of the cocrystals were reduced, and eventually the cocrystallization was inhibited to generate neat theophylline crystals. The theophylline crystals were of a distinctively different crystal structure from known polymorphs, based on powder X-ray diffraction. They were also obtained in nanoscale size, when millimeter-scale crystals formed without poly(acrylic acid). Polymeric additives that could form specific interactions with crystallizing compounds seem to be useful tools for the phase and size control of pharmaceutical crystals. (C) 2015 Elsevier B.V. All rights reserved.
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Collections - College of Engineering > Department of Chemical Engineering > 1. Journal Articles
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